Flynn, CM ; Garbers, Y ; Düsterhöft, S ; Wichert, R ; Lokau, J ; Lehmann, CHK ; Dudziak, D ; Schröder, B ; Becker-Pauly, Christoph ; Rose-John, Stefan ; Aparicio-Siegmund, S ; Garbers, C:
Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro .
In: Sci Rep (2020), Nr. 10, S. 21612

Scharfenberg, Franka ; Helbig A ; Sammel, M ; Benzel, J ; Schlomann, U ; Peters, F ; Wichert, R ; Bettendorff, M ; Schmidt-Arras, Dirk ; Rose-John, Stefan ; Lichtenthaler, SF ; Pietrzik, CU ; Bartsch, JW ; Tholey, A ; Becker-Pauly, Christoph ; Moali, C :
Degradome of soluble ADAM10 and ADAM17 metalloproteases .
In: Cellular and Molecular Life Sciences (2020), Nr. 77, S. 331-350

Escrig, A ; Molinero, A ; Méndez, B ; Giralt, M ; Comes, G ; Sanchis, P ; Fernández-Gayol, O ; Giménez-Llort, L ; Becker-Pauly, Christoph ; Rose-John, Stefan ; Hidalgo, J:
IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease .
In: Cells (2020), Nr. 9, S. 1605

Arnold, P ; Lückstädt, W ; Li, W ; Boll, I ; Lokau, J ; Garbers, C ; Lucius, R ; Rose-John, Stefan ; Becker-Pauly, Christoph:
Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles .
In: Cells (2020), Nr. 9, S. 1307

Sammel, M ; Peters, F ; Lokau, J ; Scharfenberg, Franka ; Werny, Ludwig ; Linder, S ; Garbers, C ; Rose-John, Stefan ; Becker-Pauly, Christoph:
Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP .
In: Int J Mol Sci (2019), Nr. 20, S. pii: E3677

Escrig, A ; Canal, C ; Sanchis, P ; Fernández-Gayol, O ; Montilla, A ; Comes, G ; Molinero, A ; Giralt, M ; Giménez-Llort, L ; Becker-Pauly, Christoph ; Rose-John, Stefan ; Hidalgo, J:
IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease .
In: Brain Behav Immun (2019), Nr. 82, S. 145-159

Wichert, R ; Scharfenberg, Franka ; Bülck, Cynthia ; Koudelka, T ; Schwarz, J ; Wetzel, S ; Potempa, B ; Potempa, J, ; Bartsch, JW ; Sagi, I ; Tholey, A ; Saftig, Paul ; Rose-John, Stefan ; Becker-Pauly, Christoph:
Meprin beta induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage .
In: FASEB J (2019), Nr. 33, S. 11925-11940

Wichert R ; Scharfenberg, Franka ; Bülck, Cynthia ; Koudelka T ; Schwarz J ; Wetzel S ; Potempa B ; Potempa J ; Bartsch JW ; Sagi I ; Tholey A ; Saftig, Paul ; Rose-John, Stefan ; Becker-Pauly, Christoph:
Meprin ß induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage .
In: FASEB J (2019), Nr. 33, S. 11925-11940

Schmidt, S ; Schumacher, Neele ; Schwarz, J ; Tangermann, S ; Kenner, L ; Schlederer, M ; Sibilia, M ; Linder, M ; Altendorf-Hofmann, A ; Knösel, T ; Gruber, ES ; Oberhuber, G ; Bolik, Julia ; Rehman, A ; Sinha, A ; Lokau, Juliane ; Arnold, P ; Cabron, Anne-Sophie ; Zunke, Friederike ; Becker-Pauly, Christoph ; Preaudet, A ; Nguyen, P ; Huynh, J ; Afshar-Sterle, S ; Chand, AL ; Westermann J ; Dempsey PJ ; Garbers, Christoph ; Schmidt-Arras, Dirk ; Rosenstiel P ; Putoczki T ; Ernst M ; Rose-John, Stefan:
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. .
In: J Exp Med (2018), Nr. 215, S. 1205-1225

Bedau, T ; Schumacher, Neele ; Peters, Florian ; Prox, J ; Arnold, P ; Koudelka, T ; Helm, O ; Schmidt, F ; Rabe, B ; Jentzsch, M ; Rosenstiel, P ; Sebens, S ; Tholey, A ; Rose-John, Stefan ; Becker-Pauly, Christoph:
Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro. .
In: Oncotarget (2017), Nr. 8, S. 54873-54888

Arnold P, ; Boll I, ; Rothaug, Michelle ; Pickhinke U, ; Schumacher, Neele ; Frederike Schmidt F, ; Wichert, Rielana ; Schneppenhein J, ; Lokau, Juliane ; Koudelka T, ; Tholey A, ; Rabe, Björn ; Scheller J, ; Garbers, Christoph ; Rose-John, Stefan ; Becker-Pauly, Christoph:
Meprin Metalloproteases shed and release soluble Interleukin-6 Receptor for trans-signaling .
In: Sci Rep (2017), Nr. 7, S. 44053

Wichert, Rielana ; Ermund, A ; Schmidt, S ; Schweinlin, M ; Ksiazek, M ; Arnold, P ; Knittler, K ; Wilkens, F ; Potempa, B ; Rabe, B ; Stirnberg, M ; Lucius, R ; Bartsch, JW ; Nikolaus, S ; Falk-Paulsen, M ; Rosenstiel, P ; Metzger, M ; Rose-John, Stefan ; Potempa, J ; Hansson, GC ; Dempsey, PJ ; Becker-Pauly, Christoph:
Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. .
In: Cell Rep (2017), Nr. 21, S. 2090-2103

Riethmueller S ; Somasundaram P ; Ehlers JC ; Hung CW ; Flynn, Charlotte ; Lokau, Juliane ; Agthe, Maria ; Düsterhöft S ; Zhu Y ; Grötzinger, Joachim ; Lorenzen I ; Koudelka T ; Yamamoto K ; Pickhinke U ; Wichert, Rielana ; Becker-Pauly, Christoph ; Rädisch M ; Albrecht A ; Hessefort M ; Stahnke D ; Unverzagt C ; Rose-John, Stefan ; Tholey A ; Garbers, Christoph:
Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation .
In: PLoS Biol (2017), Nr. 15, S. e2000080

Kalinin D ; Wagner S ; Riemann B ; Hermann S ; Schmidt, Frederike ; Becker-Pauly, Christoph ; Rose-John, Stefan ; Schäfers M ; Holl R:
Novel Potent Proline-based Metalloproteinase Inhibitors: Design, (Radio)Synthesis and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography .
In: J Med Chem (2016), Nr. 59, S. 9541-9559

Rothaug, Michelle ; Becker-Pauly, Christoph ; Rose-John, Stefan:
The role of interleukin-6 signaling in nervous tissue. .
In: Biochim Biophys Acta (2016), Nr. 1863, S. 1218-1227

Tucher, J ; Linke, D ; Koudelka, T ; Cassidy, L ; Tredup geb. Broder, Claudia ; Wichert, Rielana ; Pietrzik, C ; Becker-Pauly, Christoph ; Tholey, A:
LC-MS Based Cleavage Site Profiling of the Proteases ADAM10 and ADAM17 Using Proteome-Derived Peptide Libraries. .
In: J Proteome Res (2014), Nr. 13, S. 2205-2214

Becker-Pauly, Christoph ; Tredup geb. Broder, Claudia ; Prox, Johannes ; Koudelka, T ; Tholey, A :
Mapping orphan proteases by proteomics: Meprin metalloproteases deciphered as potential therapeutic targets. .
In: Proteomics Clin Appl (2014),
[doi>10.1002/prca.201300079]

Tredup geb. Broder, Claudia ; Arnold, P ; Vadon-Le Goff, S ; Konerding, MA ; Bahr, K ; Müller S ; Overall, CM ; Bond, JS ; Koudelka T ; Tholey A ; Hulmes DJ ; Moali C ; Becker-Pauly, Christoph:
Metalloproteases meprin alpha and meprin beta are C- and N-procollagen proteinases important for collagen assembly and tensile strength. .
In: Proc Natl Acad Sci U S A. (2013), Nr. 110, S. 14219-24

Schwarz, Jeanette ; Tredup geb. Broder, Claudia ; Helmstetter A ; Schmidt, Stefanie ; Yan I ; Müller, Miryam ; Schmidt-Arras, Dirk ; Becker-Pauly, Christoph ; Koch-Nolte F ; Mittrücker HW ; Rabe, Björn ; Rose-John, Stefan ; Chalaris-Rißmann, Athena:
Short-term TNFa shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17. .
In: Biochim Biophys Acta (2013), Nr. 1833, S. 3355-3367

Tredup geb. Broder, Claudia ; Becker-Pauly, Christoph:
The metalloproteases meprin alpha and meprin beta unique enzymes in inflammation, neurodegeneration, cancer and fibrosis. .
In: Biochem J (2013), Nr. 450, S. 253-64

Jefferson, T ; auf dem Keller, U ; Bellac, C ; Metz, VV ; Tredup geb. Broder, Claudia ; Hedrich, J ; Ohler, A ; Maier, W ; Magdolen, V ; Sterchi, E ; Bond, JS ; Jayakumar, A ; Traupe, H ; Chalaris-Rißmann, Athena ; Rose-John, Stefan ; Pietrzik, CU ; Postina, R ; Overall, CM ; Becker-Pauly, Christoph:
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin _{and ADAM10.} .
In: Cell Mol Life Sci (2013), Nr. 70, S. 309-333

Becker-Pauly, Christoph ; Rose-John, Stefan:
TNFa cleavage beyond TACE/ADAM17: Matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis. .
In: EMBO Mol Med (2013), Nr. 5, S. 902-904

Minder, P ; Bayha, E ; Becker-Pauly, Christoph ; Sterchi, EE :
Meprin alpha transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. .
In: J Biol Chem (2012), Nr. 287, S. 35201-11

Geurts, N ; Becker-Pauly, Christoph ; Martens, E ; Proost, P ; Van den Steen, PE ; Stöcker, W ; Opdenakker, G:
Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3. .
In: FEBS Lett. (2012), Nr. 586, S. 4

Bijakowski, C ; Vadon-Le Goff, S ; Delolme, F ; Bourhis, JM ; Lécorché, P ; Ruggiero, F ; Becker-Pauly, Christoph ; Yiallouros, I ; Stöcker, W ; Dive, V ; Hulmes, DJ ; Moali, C:
Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases. .
In: J Biol Chem. (2012), Nr. 287, S. 33581-93

Arolas, JL ; Tredup geb. Broder, Claudia ; Jefferson, T ; Guevara, T ; Sterchi, EE ; Bode, W Stöcker, W ; Becker-Pauly, Christoph ; C Gomis-Rüth, FX:
Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane. .
In: Proc Natl Acad Sci U S A. (2012), Nr. 109, S. 16131-6

Bienemann, Johannes Maria ; Jefferson, T ; Causevic, M ; Jumpertz, T ; Munter, L ; Multhaup, G ; Weggen, S ; Becker-Pauly, Christoph ; Pietrzik, CU:
The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species. .
In: J Biol Chem (2012), Nr. 287, S. 33304-13

Ohler, A ; Becker-Pauly, Christoph:
TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections. .
In: Biol Chem (2012), Nr. 393, S. 907-14

Becker-Pauly, Christoph ; Ghatei, MA ; Bloom, SR ; Murphy, KG:
A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36. Addison ML, Minnion JS, Shillito JC, Suzuki K, Tan TM, Field BC, Germain-Zito N, .
In: Endocrinology (2011), Nr. 152, S. 4630-40

Lottaz, D ; Maurer, CA ; Noël, A ; Blacher, S ; Huguenin, M ; Nievergelt, A ; Niggli, V ; Kern, A ; Müller, S ; Seibold, F ; Friess, H ; Becker-Pauly, Christoph ; Stöcker, W ; Sterchi, EE:
Enhanced activity of meprin-alpha, a pro-migratory and pro-angiogenic protease, in colorectal cancer. .
In: PLoS One (2011), Nr. 6, S. e26450

Jefferson, T ; Causevic M ; auf dem Keller, U ; Schilling, O ; Isbert, S ; Geyer, R ; Maier, W ; Tschickardt, S ; Jumpertz, T ; Weggen, S ; Bond, JS ; Overall, CM ; Pietrzik, CU ; Becker-Pauly, Christoph:
Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. .
In: J Biol Chem (2011), Nr. 286, S. 27741-50

Ohler, A ; Becker-Pauly, Christoph:
Morpholino knockdown of the ubiquitously expressed transmembrane serine protease TMPRSS4a in zebrafish embryos exhibits severe defects in organogenesis and cell adhesion. .
In: Biol Chem (2011), Nr. 392, S. 653-64

Becker-Pauly, Christoph ; Barré, O ; Schilling O ; Auf dem Keller, U ; Ohler, A ; Tredup geb. Broder, Claudia ; Schütte, A ; Kappelhoff, R ; Stöcker, W:
Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. .
In: Mol Cell Proteomics (2011), Nr. 10, S. M111.009233

Biniossek, ML ; Nägler, DK ; Becker-Pauly, Christoph ; Schilling, O:
Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S. .
In: J Proteome Res (2011), Nr. 10, S. 5363-73

Vazeille, E ; Bringer, MA ; Gardarin, A ; Chambon, C ; Becker-Pauly, Christoph ; Pender, SL ; Jakob, C ; Müller, S ; Lottaz, D ; Darfeuille-Michaud, A:
Role of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coli. .
In: PLoS One (2011), Nr. 6, S. e21199

Ohler, A ; Debela, M ; Wagner, S ; Magdolen, V ; Becker-Pauly, Christoph:
Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation. .
In: Biol Chem (2010), Nr. 391, S. 455-60

Hedrich, J ; Lottaz, D ; Meyer, K ; Yiallouros, I ; Jahnen-Dechent, W ; Stöcker, W ; Becker-Pauly, Christoph:
Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases .
In: Biochemistry (2010), Nr. 49, S. 8599-607

Schütte, A ; Hedrich, J ; Stöcker, W ; Becker-Pauly, Christoph:
Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2. .
In: PLoS One (2010), Nr. 5, S. e8835

Kronenberg, D ; Bruns, BC ; Moali, C ; Vadon-Le Goff, S ; Sterchi, EE ; Traupe, H ; Böhm, M ; Hulmes, DJ ; Stöcker, W ; Becker-Pauly, Christoph:
Processing of procollagen III by meprins: new players in extracellular matrix assembly?
In: J Invest Dermatol (2010), Nr. 130, S. 2727-35

Ambort, D ; Brellier, F ; Becker-Pauly, Christoph ; Stöcker, W ; Andrejevic-Blant, S ; Chiquet, M ; Sterchi, EE:
Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading. .
In: Matrix Biol (2010), Nr. 29, S. 31-42

Becker-Pauly, Christoph ; Bruns, BC ; Damm, O ; Schütte, A ; Hammouti, K ; Burmester, T ; Stöcker, W:
News from an ancient world: two novel astacin metalloproteases from the horseshoe crab. .
In: J Mol Biol (2009), Nr. 385, S. 236-48

Aufenvenne, K ; Oji, V ; Walker, T ; Becker-Pauly, Christoph ; Hennies, HC ; Stöcker, W ; Traupe, H:
Transglutaminase-1 and bathing suit ichthyosis: molecular analysis of gene/environment interactions. .
In: J Invest Dermatol (2009), Nr. 129, S. 2068-71

Oneda, B ; Lods, N ; Lottaz, D ; Becker-Pauly, Christoph ; Stöcker, W ; Pippin, J ; Huguenin, M ; Ambort, D ; Marti, HP ; Sterchi, EE:
Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis. .
In: PLoS One (2008), Nr. 3, S. e2278

Borchert, N ; Becker-Pauly, Christoph ; Wagner, A ; Fischer, P ; Stöcker, W ; Brattig, NW:
Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus. .
In: Microbes Infect (2007), Nr. 9, S. 498-506

Becker-Pauly, Christoph ; Höwel, M ; Walker, T ; Vlad, A ; Aufenvenne, K ; Oji, V ; Lottaz, D ; Sterchi, EE:
The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation. .
In: J Invest Dermatol (2007), Nr. 127, S. 1115-25

Becker-Pauly, Christoph ; Höwel, M ; Walker, T ; Vlad, A ; Aufenvenne, K ; Oji, V ; Lottaz, D ; Sterchi, EE:
The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation. .
In: J Invest Dermatol (2007), Nr. 127, S. 1115-25

Schütte, A ; Lottaz, D ; Sterchi, EE ; Stöcker, W ; Becker-Pauly, Christoph:
Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio. .
In: Biol Chem (2007), Nr. 388, S. 523-31

Hintze, V ; Höwel, M ; Wermter, C ; Grosse Berkhoff, E ; Becker-Pauly, Christoph ; Beermann, B ; Yiallouros, I ; Stöcker, W:
The interaction of recombinant subdomains of the procollagen C-proteinase with procollagen I provides a quantitative explanation for functional differences between the two splice variants, mammalian tolloid and bone morphogenetic protein 1. .
In: Biochemistry (2006), Nr. 45, S. 6741-8

Kruse, M.N ; Becker-Pauly, Christoph ; Lottaz, D ; Köhler, D ; Yiallouros, I ; Krell, HW ; Sterchi, EE ; Stöcker, W:
Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. .
In: Biochemical Journal (2004), Nr. 378, S. 383-389

Becker-Pauly, Christoph ; Kruse, MN ; Slotty, K A ; Köhler, D ; Harris, JR ; Rösmann, S ; Sterchi, EE ; Stöcker, W:
Differences in the Activation Mechanism between the alpha and beta Subunits of Human Meprin. .
In: Biological Chemistry (2003), Nr. 384, S. 825-831