Our bioprospecting efforts are directed at understanding the true biosynthetic potential of marine invertebrates (sponges, tunicates), fish, macrophytes as well their associated microbiota for discovery of bioactive secondary metabolites for potential development. We address global health challenges, by focusing on e.g., cancer, and pathogens causing diseases in human, crops, food or aquaculture. Macroorganisms will be extracted automatically using green extraction techniques, such as ASE and SFE. When working with microorganisms (bacteria and fungi), we apply innovative techniques to i) increase their cultivability in laboratory conditions, and ii) activate their silent biosynthetic gene clusters (e.g., by co-cultivation) to produce new metabolites. Any organism with high bioactivity and novel chemistry will be submitted to discovery pipeline for purification (HPLC and others) and 3D chemical characterization (NMR, MS and other spectroscopic techniques) of new molecules. Purification of target (new) compounds is monitored by MS-based metabolomics, bioinformatics and bioassays. We are also interested in valorization of waste material.

Selected publications:

Oppong-Danquah, E. , Miranda, M., Blümel, M., Tasdemir, D. (2023) Bioactivity Profiling and Untargeted Metabolomics of Microbiota Associated with Mesopelagic Jellyfish Periphylla periphylla. Marine Drugs, 21 (2). Art.Nr. 129. DOI 10.3390/md21020129.

Magot, F., Van Soen, G., Buedenbender, L., Li, F., Soltwedel, T., Grauso, L., Mangoni, A., Blümel, M. und Tasdemir, D. (2023) Bioactivity and Metabolome Mining of Deep-Sea Sediment-Derived Microorganisms Reveal New Hybrid PKS-NRPS Macrolactone from Aspergillus versicolor PS108-62.  Marine Drugs, 21 (2). Art.Nr. 95. DOI 10.3390/md21020095.

Vitale, G. A., January, G. G., Oppong-Danquah, E. , Della Sala, G., Palma Esposito, F., Tasdemir, D. und de Pascale, D. (2023) A metabologenomics approach to unlock the metabolome of the novel Antarctic deep-sea isolate Lacinutrix shetlandiensis sp. nov. WUR7.  PNAS Nexus, 2 (7). Art.Nr. pgad221. DOI 10.1093/pnasnexus/pgad221.

Eroldoğan, O. T., Glencross, B., Novoveska, L., Gaudêncio, S. P., Rinkevich, B., Varese, G. C., de Fátima Carvalho, M., Tasdemir, D. , Safarik, I., Nielsen, S. L., Rebours, C., Lada, L. B., Robbens, J., Strode, E., Haznedaroğlu, B. Z., Kotta, J., Evliyaoğlu, E., Oliveira, J., Girão, M., Vasquez, M. I., Čabarkapa, I., Rakita, S., Klun, K. und Rotter, A. (2023) From the sea to aquafeed: A perspective overview.  Reviews in Aquaculture, 15 (3). pp. 1028-1057. DOI 10.1111/raq.12740.

Freitas, S., Castelo-Branco, R., Wenzel-Storjohann, A., Vasconcelos, V. M., Tasdemir, D. und Leão, P. N. (2022) Structure and Biosynthesis of Desmamides A–C, Lipoglycopeptides from the Endophytic Cyanobacterium Desmonostoc muscorum LEGE 12446.  Journal of Natural Products, 85 (7). pp. 1704-1714. DOI 10.1021/acs.jnatprod.2c00162.

Ghotbi, M., Kelting, O., Blümel, M. und Tasdemir, D. (2022) Gut and Gill-Associated Microbiota of the Flatfish European Plaice (Pleuronectes platessa): Diversity, Metabolome and Bioactivity against Human and Aquaculture Pathogens.  Marine Drugs, 20 (9). Art.Nr. 573. DOI 10.3390/md20090573.

Oppong-Danquah, E., Blümel, M., Scarpato, S., Mangoni, A. und Tasdemir, D. (2022) Induction of Isochromanones by Co-Cultivation of the Marine Fungus Cosmospora sp. and the Phytopathogen Magnaporthe oryzae.  International Journal of Molecular Sciences, 23 (2). Art.Nr. 782. DOI 10.3390/ijms23020782.

Rudovica, V., Rotter, A., Gaudêncio, S. P., Novoveská, L., Akgül, F., Akslen-Hoel, L. K., Alexandrino, D. A. M., Anne, O., Arbidans, L., Atanassova, M., Bełdowska, M., Bełdowski, J., Bhatnagar, A., Bikovens, O., Bisters, V., Carvalho, M. F., Catalá, T. S., Dubnika, A., Erdoğan, A., Ferrans, L., Haznedaroglu, B. Z., Setyobudi, R. H., Graca, B., Grinfelde, I., Hogland, W., Ioannou, E., Jani, Y., Kataržytė, M., Kikionis, S., Klun, K., Kotta, J., Kriipsalu, M., Labidi, J., Lukić Bilela, L., Martínez-Sanz, M., Oliveira, J., Ozola-Davidane, R., Pilecka-Ulcugaceva, J., Pospiskova, K., Rebours, C., Roussis, V., López-Rubio, A., Safarik, I., Schmieder, F., Stankevica, K., Tamm, T., Tasdemir, D. , Torres, C., Varese, G. C., Vincevica-Gaile, Z., Zekker, I. und Burlakovs, J. (2021) Valorization of Marine Waste: Use of Industrial By-Products and Beach Wrack Towards the Production of High Added-Value Products.  Frontiers in Marine Science, 8. Art.Nr. 723333. DOI 10.3389/fmars.2021.723333.

Di, X. , Wang, S., Oskarsson, J. T., Rouger, C., Tasdemir, D. , Hardardottir, I., Freysdottir, J., Wang, X. , Molinski, T. F.  und Omarsdottir,  S. (2020) Bromotryptamine and Imidazole Alkaloids with Anti-inflammatory Activity from the Bryozoan Flustra foliacea. Journal of Natural Products, 83 (10). pp. 2854-2866. DOI 10.1021/acs.jnatprod.0c00126.

Li, F. , Pandey, P. , Janussen, D. , Chittiboyina, A. G. , Ferreira, D.  und Tasdemir, D.  (2020) Tridiscorhabdin and Didiscorhabdin, the First Discorhabdin Oligomers Linked with a Direct C–N Bridge from the Sponge Latrunculia biformis Collected from the Deep Sea in Antarctica. Journal of Natural Products, 83 (3). pp. 706-713. DOI 10.1021/acs.jnatprod.0c00023.

Oppong-Danquah, E., Budnicka, P., Blümel, M.  und Tasdemir, D.  (2020) Design of Fungal Co‐Cultivation Based on Comparative Metabolomics and Bioactivity for Discovery of Marine Fungal Agrochemicals.  Marine Drugs, 18 (2). Art.Nr. 73. DOI 10.3390/md18020073.

Oppong-Danquah, E., Parrot, D., Blümel, M., Labes, A. und Tasdemir, D. (2018) Molecular Networking-Based Metabolome and Bioactivity Analyses of Marine-Adapted Fungi Co-cultivated With Phytopathogens.  Frontiers in Microbiology, 9 . Art.Nr. 2072. DOI 10.3389/fmicb.2018.02072.

Chianese, G., Silber, J., Luciano, P., Merten, C., Erpenbeck, D., Topaloglu, B., Kaiser, M. und Tasdemir, D. (2017) Antiprotozoal Linear Furanosesterterpenoids from the Marine Sponge Ircinia oros. Journal of Natural Products, 80 (9). pp. 2566-2571. DOI 10.1021/acs.jnatprod.7b00543.