Liebsch F ; Kulic L ; Teunissen C ; Shobo A ; Ulku I ; Engelschalt V ; Hancock MA ; van der Flier WM ; Kunach P ; Rosa-Neto P ; Scheltens P ; Poirier J ; Saftig, Paul ; Bateman RJ ; Breitner J ; Hock C ; Multhaup G:
Aß34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression .
In: Nat Commun (2019), Nr. 10, S. 2240

Notomi S ; Ishihara K ; Efstathiou NE ; Lee JJ ; Hisatomi T ; Tachibana T ; Konstantinou EK ; Ueta T ; Murakami Y ; Maidana DE ; Ikeda Y ; Kume S ; Terasaki H ; Sonoda S ; Blanz J ; Young L ; Sakamoto T ; Sonoda KH ; Saftig, Paul ; Ishibashi T ; Miller JW ; Kroemer G ; Vavvas DG:
Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina .
In: Proc Natl Acad Sci U S A (2019), Nr. 116, S. 23724-23734

Vezzoli E ; Caron I ; Talpo F ; Besusso D ; Conforti P ; Battaglia E ; Sogne E ; Falqui A ; Petricca L ; Verani M ; Martufi P ; Caricasole A ; Bresciani A ; Cecchetti O ; Rivetti di Val Cervo P ; Sancini G ; Riess O ; Nguyen H ; Seipold L ; Saftig, Paul ; Biella G ; Cattaneo E ; Zuccato C:
Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease .
In: J Clin Invest (2019), Nr. 129, S. 2390-2403

Pasquier A ; Vivot K ; Erbs E ; Spiegelhalter C ; Zhang Z ; Aubert V ; Liu Z ; Senkara M ; Maillard E ; Pinget M ; Kerr-Conte J ; Pattou F ; Marciniak G ; Ganzhorn A ; Ronchi P ; Schieber NL ; Schwab Y ; Saftig, Paul ; Goginashvili A ; Ricci R:
Lysosomal degradation of newly formed insulin granules contributes to ß cell failure in diabetes .
In: Nat Commun (2019), Nr. 10, S. 3312

Heybrock, Saskia ; Kanerva K ; Meng Y ; Ing C ; Liang A ; Xiong ZJ ; Weng X ; Ah Kim Y ; Collins R ; Trimble W ; Pomès R ; Privé GG ; Annaert W ; Schwake M ; Heeren J ; Lüllmann-Rauch R ; Grinstein S ; Ikonen E ; Saftig, Paul ; Neculai D:
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export .
In: Nat Commun (2019), Nr. 10, S. 3521
[doi>10.1038/s41467-019-11425-0]

Marques ARA ; Saftig, Paul:
Lysosomal storage disorders - challenges, concepts and avenues for therapy: beyond rare diseases .
In: J Cell Sci (2019), Nr. 132, S. jcs221739

Wichert, R ; Scharfenberg, Franka ; Bülck, Cynthia ; Koudelka, T ; Schwarz, J ; Wetzel, S ; Potempa, B ; Potempa, J, ; Bartsch, JW ; Sagi, I ; Tholey, A ; Saftig, Paul ; Rose-John, Stefan ; Becker-Pauly, Christoph:
Meprin beta induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage .
In: FASEB J (2019), Nr. 33, S. 11925-11940

Wichert R ; Scharfenberg, Franka ; Bülck, Cynthia ; Koudelka T ; Schwarz J ; Wetzel S ; Potempa B ; Potempa J ; Bartsch JW ; Sagi I ; Tholey A ; Saftig, Paul ; Rose-John, Stefan ; Becker-Pauly, Christoph:
Meprin ß induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage .
In: FASEB J (2019), Nr. 33, S. 11925-11940

Li X ; Qin L ; Li Y ; Yu H ; Zhang Z ; Tao C ; Liu Y ; Xue Y ; Zhang X ; Xu Z ; Wang Y ; Lou H ; Tan Z ; Saftig, Paul ; Chen Z ; Xu T ; Bi G ; Duan S ; Gao Z:
Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles .
In: Cell Rep (2019), Nr. 28, S. 1015-1028

Niemeyer J ; Mentrup T ; Heidasch R ; Müller SA ; Biswas U ; Meyer R ; Papadopoulou AA ; Dederer V ; Haug-Kröper M ; Adamski V ; Lüllmann-Rauch R ; Bergmann M ; Mayerhofer A ; Saftig, Paul ; Wennemuth G ; Jessberger R ; Fluhrer R ; Lichtenthaler SF ; Lemberg MK ; Schröder B:
The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban .
In: EMBO Rep (2019), Nr. 20, S. e46449

Massa López D ; Thelen M ; Stahl F ; Thiel C ; Linhorst A ; Sylvester M ; Hermanns-Borgmeyer I ; Lüllmann-Rauch R ; Eskild W ; Saftig, Paul ; Damme, Markus:
The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP .
In: Elife (2019), Nr. 8, S. pii: e50025. doi: 10.7554/eLife.50025

Reinicke AT ; Laban K ; Sachs M ; Kraus V ; Walden M ; Damme, Markus ; Sachs W ; Reichelt J ; Schweizer M ; Janiesch PC ; Duncan KE ; Saftig, Paul ; Rinschen MM ; Morellini F ; Meyer-Schwesinger C:
Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks .
In: Proc Natl Acad Sci U S A (2019), Nr. 116, S. 7963-7972

Seipold L ; Altmeppen H ; Koudelka T ; Tholey A ; Kasparek P ; Sedlacek R ; Schweizer M ; Bär J ; Mikhaylova M ; Glatzel M ; Saftig, Paul:
In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15. .
In: Cell Mol Life Sci (2018), Nr. 75, S. 3251-3267

Gonzalez AC ; Stroobants S ; Reisdorf P ; Gavin AL ; Nemazee D ; Schwudke D ; D'Hooge R ; Saftig, Paul ; Damme, Markus:
PLD3 and spinocerebellar ataxia .
In: Brain (2018), Nr. 141, S. e78

Linsenmeier L ; Mohammadi B ; Wetzel S ; Puig B ; Jackson WS ; Hartmann A ; Uchiyama K ; Sakaguchi S ; Endres K ; Tatzelt J ; Saftig, Paul ; Glatzel M ; Altmeppen HC:
Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein .
In: Mol Neurodegener (2018), Nr. 13, S. 18

Pohl S ; Angermann A ; Jeschke A ; Hendrickx G ; Yorgan TA ; Makrypidi-Fraune G ; Steigert A ; Kuehn SC ; Rolvien T ; Schweizer M ; Koehne T ; Neven M ; Winter O ; Velho RV ; Albers J ; Streichert T ; Pestka JM ; Baldauf C ; Breyer S ; Stuecker R ; Muschol N ; Cox TM ; Saftig, Paul ; Paganini C ; Rossi A ; Amling M ; Braulke T ; Schinke T:
The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover .
In: J Bone Miner Res (2018), Nr. 33, S. 2186-2201

Gonzalez AC ; Schweizer M ; Jagdmann S ; Bernreuther C ; Reinheckel T ; Saftig, Paul ; Damme, Markus:
Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes .
In: Cell Rep (2018), Nr. 22, S. 1040-1053

Bartsch K ; Knittler K ; Borowski C ; Rudnik, Sönke ; Damme, Markus ; Aden, Konrad ; Spehlmann ME ; Frey, Norbert ; Saftig, Paul ; Chalaris A ; Rabe B:
Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy .
In: Hum Mol Genet (2017), Nr. 26, S. 3960-3972

Kissing S ; Rudnik S ; Damme, Markus ; Lüllmann-Rauch R ; Ichihara A ; Kornak U ; Eskelinen EL ; Jabs S ; Heeren J ; De Brabander JK ; Haas A ; Saftig, Paul:
Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes .
In: Autophagy (2017), Nr. 13, S. 670-685

Linsenmeier L. ; Altmeppen HC ; Wetzel S ; Mohammadi B ; Saftig, Paul ; Glatzel M.:
Diverse functions of the prion protein - Does proteolytic processing hold the key?
In: Biochim Biophys Acta Mol Cell Res (2017), Nr. 1864, S. 2128-2137

Nguyen TL ; Schneppenheim J ; Rudnik S ; Lüllmann-Rauch R ; Bernreuther C ; Hermans-Borgmeyer I ; Glatzel M ; Saftig, Paul ; Schröder B:
Functional characterization of the lysosomal membrane protein TMEM192 in mice .
In: Oncotarget (2017), Nr. 8, S. 43635-43652

Cheng S ; Wani WY ; Hottman DA ; Jeong A ; Cao D ; LeBlanc KJ ; Saftig, Paul ; Zhang J ; Li L:
Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice .
In: J Neurochem (2017), Nr. 142, S. 297-304

Liu H ; Javaheri A ; Godar RJ ; Murphy J ; Ma X ; Rohatgi N ; Mahadevan J ; Hyrc K ; Saftig, Paul ; Marshall C ; McDaniel ML ; Remedi MS ; Razani B ; Urano F ; Diwan A:
Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway .
In: Autophagy (2017), Nr. 13, S. 1952-1968

Stroobants S ; Damme, Markus ; Van der Jeugd A ; Vermaercke B ; Andersson C ; Fogh J ; Saftig, Paul ; Blanz J ; D'Hooge R:
Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice .
In: Neurobiol Dis (2017), Nr. 106, S. 255-268

Conrad KS ; Cheng TW ; Ysselstein D ; Heybrock S ; Hoth LR ; Chrunyk BA ; Am Ende CW ; Krainc D ; Schwake M ; Saftig, Paul ; Liu S ; Qiu X ; Ehlers MD:
Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies .
In: Nat Commun (2017), Nr. 8, S. 1908

Beel S ; Moisse MP ; Damme, Markus ; De Muynck L ; Robberecht W ; Van Den Bosch L ; Saftig, Paul ; Van Damme P:
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo .
In: Hum Mol Genet (2017), Nr. 26, S. 2850-2863

Markmann S ; Krambeck S ; Hughes CJ ; Mirzaian M ; Aerts JM ; Saftig, Paul ; Schweizer M ; Vissers JP ; Braulke T ; Damme, Markus:
Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II. .
In: Mol Cell Proteomics (2017), Nr. 16, S. 438-450

Petersen W ; Stenzel W ; Silvie O ; Blanz J ; Saftig, Paul ; Matuschewski K ; Ingmundson A:
Sequestration of cholesterol within the host late endocytic pathway restricts liver-stage Plasmodium development .
In: Mol Biol Cell (2017), Nr. 28, S. 726-735

Stavropoulou AV ; Mavrofrydi O ; Saftig, Paul ; Efthimiopoulos S:
Serum Starvation Induces BACE1 Processing and Secretion .
In: Curr Alzheimer Res (2017), Nr. 14, S. 453-459

Seipold L ; Damme, Markus ; Prox J ; Rabe B ; Kasparek P ; Sedlacek R ; Altmeppen H ; Willem M ; Boland B ; Glatzel M ; Saftig, Paul:
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein .
In: Biochim Biophys Acta Mol Cell Res (2017), Nr. 1864, S. 217-230

Schulze U ; Brast S ; Grabner A ; Albiker C ; Snieder B ; Holle S ; Schlatter E ; Schröter R ; Pavenstädt H ; Herrmann E ; Lambert C ; Spoden GA ; Florin L ; Saftig, Paul ; Ciarimboli G:
Tetraspanin CD63 controls basolateral sorting of organic cation transporter 2 in renal proximal tubules .
In: FASEB J (2017), Nr. 31, S. 1421-1433

Schneppenheim J ; Loock AC ; Hüttl S ; Schweizer M ; Lüllmann-Rauch R ; Oberg HH ; Arnold P ; Lehmann CHK ; Dudziak D ; Kabelitz D ; Lucius R ; Lennon-Duménil AM ; Saftig, Paul ; Schröder B.:
The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments .
In: J Immunol (2017), Nr. 199, S. 172-185

Wetzel S ; Seipold L ; Saftig, Paul:
The metalloproteinase ADAM10: A useful therapeutic target?
In: Biochim Biophys Acta Mol Cell Res (2017), Nr. 1864, S. 2071-2081

Müller, Miryam ; Wetzel, Sebastian ; Köhn-Gaone J ; Chalupsky K ; Lüllmann-Rauch R ; Barikbin R ; Bergmann J ; Wöhner B ; Zbodakova O ; Leuschner I ; Martin G ; Tiegs G ; Rose-John, Stefan ; Sedlacek R ; Tirnitz-Parker JE ; Saftig, Paul ; Schmidt-Arras, Dirk:
A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis. .
In: Oncotarget (2016), Nr. 7, S. 17431-17441

Yan I ; Schwarz J ; Lücke K ; Schumacher, Neele ; Schumacher V ; Schmidt, Stefanie ; Rabe, Björn ; Saftig, Paul ; Donners M ; Rose-John, Stefan ; Mittrücker HW ; Chalaris A.:
ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses. .
In: J Leukoc Biol (2016), Nr. 99, S. 749-760

Moriya S ; Izu Y ; Arayal S ; Kawasaki M ; Hata K ; Pawaputanon Na Mahasarakhahm C ; Izumi Y ; Saftig, Paul ; Kaneko K ; Noda M ; Ezura Y:
Cathepsin K Deficiency Suppresses Disuse-Induced Bone Loss .
In: J Cell Physiol (2016), Nr. 231, S. 1163-1170

Zunke F ; Andresen L ; Wesseler S ; Groth J ; Arnold P ; Rothaug M ; Mazzulli JR ; Krainc D ; Blanz J ; Saftig, Paul ; Schwake M:
Characterization of the complex formed by ß-glucocerebrosidase and the lysosomal integral membrane protein type-2 .
In: Proc Natl Acad Sci U S A (2016), Nr. 113, S. 3791-3796

von Hoven G ; Rivas AJ ; Neukirch C ; Klein S ; Hamm C ; Qin Q ; Meyenburg M ; Füser S ; Saftig, Paul ; Hellmann N ; Postina R ; Husmann M:
Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus a-toxin action .
In: Biochem J (2016), Nr. 473, S. 1929-1940

Klionsky DJ ; große Vielzahl von Autoren ; Saftig, Paul ; Damme, Markus ; große Vielzahl von Autoren ; Zughaier SM:
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) .
In: Autophagy (2016), Nr. 12, S. 1-222

Kook S ; Wang P ; Young LR ; Schwake M ; Saftig, Paul ; Weng X ; Meng Y ; Neculai D ; Marks MS ; Gonzales L ; Beers MF ; Guttentag S:
Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice .
In: J Biol Chem (2016), Nr. 291, S. 8414-8427

Schröder B ; Saftig, Paul:
Intramembrane proteolysis within lysosomes .
In: Ageing Res Rev (2016), Nr. 32, S. 51-64

Schulze-Luehrmann J ; Eckart RA ; Ölke M ; Saftig, Paul ; Liebler-Tenorio E ; Lührmann A:
LAMP proteins account for the maturation delay during the establishment of the Coxiella burnetii-containing vacuole .
In: Cell Microbiol (2016), Nr. 18, S. 181-194

Grünwald B ; Harant V ; Schaten S ; Frühschütz M ; Spallek R ; Höchst B ; Stutzer K ; Berchtold S ; Erkan M ; Prokopchuk O ; Martignoni M ; Esposito I ; Heikenwalder M ; Gupta A ; Siveke J ; Saftig, Paul ; Knolle P ; Wohlleber D ; Krüger A:
Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver .
In: Gastroenterology (2016), Nr. 151, S. 1011-1024

Blanz J ; Saftig, Paul:
Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance .
In: J Neurochem (2016), Nr. 139, S. 198-215

Dibbens L ; Schwake M ; Saftig, Paul ; Rubboli G:
SCARB2/LIMP2 deficiency in action myoclonus-renal failure syndrome .
In: Epileptic Disord (2016), Nr. 18, S. 63-72

Hüttl S ; Helfrich F ; Mentrup T ; Held S ; Fukumori A ; Steiner H ; Saftig, Paul ; Fluhrer R ; Schröder B:
Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74 .
In: Biochem J (2016), Nr. 473, S. 1405-1422

Kuhn PH ; Colombo AV ; Schusser B ; Dreymueller D ; Wetzel S ; Schepers U ; Herber J ; Ludwig A ; Kremmer E ; Montag D ; Müller U ; Schweizer M ; Saftig, Paul ; Bräse S ; Lichtenthaler SF:
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function .
In: Elife (2016), Nr. 5, S. e12748

Seipold L ; Saftig, Paul:
The Emerging Role of Tetraspanins in the Proteolytic Processing of the Amyloid Precursor Protein .
In: Front Mol Neurosci (2016), Nr. 9, S. 149

Saftig, Paul ; Haas A:
Turn up the lysosome .
In: Nat Cell Biol (2016), Nr. 18, S. 1025-1027

Mentrup T ; Häsler R ; Fluhrer R ; Saftig, Paul ; Schröder B:
A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases .
In: Traffic (2015), Nr. 16, S. 871-892

Yan I ; Schwarz J ; Lücke K ; Schumacher N ; Schumacher V ; Schmidt S ; Rabe B ; Saftig, Paul ; Donners M ; Rose-John, Stefan ; Mittrücker HW ; Chalaris A:
ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Ra from the cell surface of leukocytes during inflammatory responses .
In: J Leukoc Biol (2015), Nr. 99, S. 749-760

Damme, Markus ; Suntio T ; Saftig, Paul ; Eskelinen EL:
Autophagy in neuronal cells: general principles and physiological and pathological functions .
In: Acta Neuropathol (2015), Nr. 129, S. 337-362

Okada R ; Wu Z ; Zhu A ; Ni J ; Zhang J ; Yoshimine Y ; Peters C ; Saftig, Paul ; Nakanishi H:
Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier .
In: Mol Cell Neurosci (2015), Nr. 64, S. 51-60

Damme, Markus ; Stroobants S ; Lüdemann M ; Rothaug M ; Lüllmann-Rauch R ; Beck HC ; Ericsson A ; Andersson C ; Fogh J ; D'Hooge R ; Saftig, Paul ; Blanz J:
Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice .
In: Ann Clin Transl Neurol (2015), Nr. 2, S. 987-1001

Rothaug M ; Stroobants S ; Schweizer M ; Peters J ; Zunke F ; Allerding M ; D'Hooge R ; Saftig, Paul ; Blanz J:
LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease .
In: Acta Neuropathol Commun (2015), Nr. 3, S. 6

Peters J ; Rittger A ; Weisner R ; Knabbe J ; Zunke F ; Rothaug M ; Damme, Markus ; Berkovic SF ; Blanz J ; Saftig, Paul ; Schwake M:
Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease .
In: Biochem Biophys Res Commun (2015), Nr. 457, S. 334-340

Blanz J ; Zunke F ; Markmann S ; Damme, Markus ; Braulke T ; Saftig, Paul ; Schwake M:
Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2 .
In: Traffic (2015), Nr. 16, S. 1127-1136

van der Vorst EP ; Jeurissen M ; Wolfs IM ; Keijbeck A ; Theodorou K ; Wijnands E ; Schurgers L ; Weber S ; Gijbels MJ ; Hamers AA ; Dreymueller D ; Rose-John, Stefan ; de Winther MP ; Ludwig A ; Saftig, Paul ; Biessen EA ; Donners MM:
Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis. .
In: Am J Pathol (2015), Nr. 185, S. 1145-1155

Hüttl S ; Kläsener K ; Schweizer M ; Schneppenheim J ; Oberg HH ; Kabelitz D ; Reth M ; Saftig, Paul ; Schröder B:
Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell Receptor Signaling in Transitional B Cells .
In: J Immunol (2015), Nr. 195, S. 1548-1563

Saftig, Paul ; Bovolenta P:
Proteases at work: cues for understanding neural development and degeneration .
In: Front Mol Neurosci (2015), Nr. 8, S. 13

Godar RJ ; Ma X ; Liu H ; Murphy JT ; Weinheimer CJ ; Kovacs A ; Crosby SD ; Saftig, Paul ; Diwan A:
Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury .
In: Autophagy (2015), Nr. 11, S. 1537-1560

Hessler S ; Zheng F ; Hartmann S ; Rittger A ; Lehnert S ; Völkel M ; Nissen M ; Edelmann E ; Saftig, Paul ; Schwake M ; Huth T ; Alzheimer C:
ß-Secretase BACE1 regulates hippocampal and reconstituted M-currents in a ß-subunit-like fashion .
In: J Neurosci (2015), Nr. 35, S. 3298-3311

Saftig, Paul ; Lichtenthaler SF:
The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain .
In: Prog Neurobiol (2015), Nr. 135, S. 1-20

Altmeppen HC ; Prox J ; Krasemann S ; Puig B ; Kruszewski K ; Dohler F ; Bernreuther C ; Hoxha A ; Linsenmeier L ; Sikorska B ; Liberski PP ; Bartsch U ; Saftig, Paul ; Glatzel M:
The sheddase ADAM10 is a potent modulator of prion disease .
In: Elife (2015), Nr. 4, S. 1

Kobuch J ; Cui H ; Grünwald B ; Saftig, Paul ; Knolle PA ; Krüger A:
TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice .
In: Haematologica (2015), Nr. 100, S. 1005-1013

Kissing S ; Hermsen C ; Repnik U ; Nesset CK ; von Bargen K ; Griffiths G ; Ichihara A ; Lee BS ; Schwake M ; De Brabander J ; Haas A ; Saftig, Paul:
Vacuolar ATPase in phagosome-lysosome fusion .
In: J Biol Chem (2015), Nr. 290, S. 14166-14180

Romi E ; Gokhman I ; Wong E ; Antonovsky N ; Ludwig A ; Sagi I ; Saftig, Paul ; Tessier-Lavigne M ; Yaron A:
ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A .
In: Nat Commun (2014), Nr. 5, S. 4058

Grimm C ; Holdt LM ; Chen CC ; Hassan S ; Müller C ; Jörs S ; Cuny H ; Kissing S ; Schröder B ; Butz E ; Northoff B ; Castonguay J ; Luber CA ; Moser M ; Spahn S ; Lüllmann-Rauch R ; Fendel C ; Klugbauer N ; Griesbeck O ; Haas A ; Mann M ; Bracher F ; Teupser D ; Saftig, Paul ; Biel M ; Wahl-Schott C:
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice .
In: Nat Commun (2014), Nr. 5, S. 4699

Pruessmeyer J ; Hess FM ; Alert H ; Groth E ; Pasqualon T ; Schwarz N ; Nyamoya S ; Kollert J ; van der Vorst E ; Donners M ; Martin C ; Uhlig S ; Saftig, Paul ; Dreymueller D ; Ludwig A:
Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space .
In: Blood (2014), Nr. 123, S. 4077-4088

Rothaug M ; Zunke F ; Mazzulli JR ; Schweizer M ; Altmeppen H ; Lüllmann-Rauch R ; Kallemeijn WW ; Gaspar P ; Aerts JM ; Glatzel M ; Saftig, Paul ; Krainc D ; Schwake M ; Blanz J:
LIMP-2 expression is critical for ß-glucocerebrosidase activity and a-synuclein clearance. .
In: Proc Natl Acad Sci U S A (2014), Nr. 111, S. 15573-15578

Groot AJ ; Habets R ; Yahyanejad S ; Hodin CM ; Reiss K ; Saftig, Paul ; Theys J ; Vooijs M:
Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins .
In: Mol Cell Biol (2014), Nr. 34, S. 2822-2832

Schneppenheim J ; Hüttl S ; Kruchen A ; Fluhrer R ; Müller I ; Saftig, Paul ; Schneppenheim R ; Martin CL ; Schröder B:
Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells .
In: Biochem Biophys Res Commun (2014), Nr. 451, S. 48-53

Müller S ; Faulhaber A ; Sieber C ; Pfeifer D ; Hochberg T ; Gansz M ; Deshmukh SD ; Dauth S ; Brix K ; Saftig, Paul ; Peters C ; Henneke P ; Reinheckel T:
The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction .
In: FASEB J (2014), Nr. 28, S. 162-175

Schneppenheim J ; Hüttl S ; Mentrup T ; Lüllmann-Rauch R ; Rothaug M ; Engelke M ; Dittmann K ; Dressel R ; Araki M ; Araki K ; Wienands J ; Fluhrer R ; Saftig, Paul ; Schröder B:
The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo .
In: Mol Cell Biol (2014), Nr. 34, S. 1398-1411

Jae LT ; Raaben M ; Herbert AS ; Kuehne AI ; Wirchnianski AS ; Soh TK ; Stubbs SH ; Janssen H ; Damme, Markus ; Saftig, Paul ; Whelan SP ; Dye JM ; Brummelkamp TR:
Virus entry. Lassa virus entry requires a trigger-induced receptor switch .
In: Science (2014), Nr. 344, S. 1506-1510

Cheret C ; Willem M ; Fricker FR ; Wende H ; Wulf-Goldenberg A ; Tahirovic S ; Nave KA ; Saftig, Paul ; Haass C ; Garratt AN ; Bennett DL ; Birchmeier C:
Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles .
In: EMBO J (2013), Nr. 32, S. 2015-2028

Saftig, Paul ; Sandhoff K:
Cancer: Killing from the inside. .
In: Nature (2013), Nr. 502, S. 312-313

Smith KR ; Dahl HH ; Canafoglia L ; Andermann E ; Damiano J ; Morbin M ; Bruni AC ; Giaccone G ; Cossette P ; Saftig, Paul ; Grötzinger J ; Schwake M ; Andermann F ; Staropoli JF ; Sims KB ; Mole SE ; Franceschetti S ; Alexander NA ; Cooper JD ; Chapman HA ; Carpenter S ; Berkovic SF ; Bahlo M:
Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis .
In: Hum Mol Genet (2013), Nr. 22, S. 1417-1423

Ulbricht A ; Eppler FJ ; Tapia VE ; van der Ven PF ; Hampe N ; Hersch N ; Vakeel P ; Stadel D ; Haas A ; Saftig, Paul ; Behrends C ; Fürst DO ; Volkmer R ; Hoffmann B ; Kolanus W ; Höhfeld J:
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy .
In: Curr Biol (2013), Nr. 23, S. 430-435

Koike M ; Shibata M ; Ezaki J ; Peters C ; Saftig, Paul ; Kominami E ; Uchiyama Y:
Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system .
In: Eur J Neurosci (2013), Nr. 37, S. 816-830

Borgwardt L ; Dali CI ; Fogh J ; Mansson JE ; Olsen KJ ; Beck HC ; Nielsen KG ; Nielsen LH ; Olsen SO ; Riise Stensland HM ; Nilssen O ; Wibrand F ; Thuesen AM ; Pearl T ; Haugsted U ; Saftig, Paul ; Blanz J ; Jones SA ; Tylki-Szymanska A ; Guffon-Fouiloux N ; Beck M ; Lund AM:
Enzyme replacement therapy for alpha-mannosidosis: 12 months follow-up of a single centre, randomised, multiple dose study .
In: J Inherit Metab Dis (2013), Nr. 36, S. 1015-1024

Groot AJ ; Cobzaru C ; Weber S ; Saftig, Paul ; Blobel CP ; Kopan R ; Vooijs M ; Franzke CW:
Epidermal ADAM17 is dispensable for notch activation .
In: J Invest Dermatol (2013), Nr. 133, S. 2286-2288

Sina C ; Lipinski S ; Gavrilova O ; Aden K ; Rehman A ; Till A ; Rittger A ; Podschun R ; Meyer-Hoffert U ; Haesler R ; Midtling E ; Pütsep K ; McGuckin MA ; Schreiber S ; Saftig, Paul ; Rosenstiel P:
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice .
In: Gut (2013), Nr. 62, S. 520-530

Schwake M ; Schröder B ; Saftig, Paul:
Lysosomal membrane proteins and their central role in physiology .
In: Traffic (2013), Nr. 14, S. 739-748

Beck M ; Olsen KJ ; Wraith JE ; Zeman J ; Michalski JC ; Saftig, Paul ; Fogh J ; Malm D:
Natural history of alpha mannosidosis a longitudinal study .
In: Orphanet J Rare Dis (2013), Nr. 8, S. 88

Schmid J ; Oelbe M ; Saftig, Paul ; Schwake M ; Schweda F:
Parallel regulation of renin and lysosomal integral membrane protein 2 in renin-producing cells: further evidence for a lysosomal nature of renin secretory vesicles .
In: Pflugers Arch (2013), Nr. 465, S. 895-905

Prox J ; Bernreuther C ; Altmeppen H ; Grendel J ; Glatzel M ; D'Hooge R ; Stroobants S ; Ahmed T ; Balschun D ; Willem M ; Lammich S ; Isbrandt D ; Schweizer M ; Horré K ; De Strooper B ; Saftig, Paul:
Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions .
In: J Neurosci (2013), Nr. 33, S. 12915-12928

Weber S ; Wetzel S ; Prox J. ; Lehmann T ; Schneppenheim J ; Donners M ; Saftig, Paul:
Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10) .
In: Biochem Biophys Res Commun (2013), Nr. 442, S. 234-241

Neculai D ; Schwake M ; Ravichandran M ; Zunke F ; Collins RF ; Peters J ; Neculai M ; Plumb J ; Loppnau P ; Pizarro JC ; Seitova A ; Trimble WS ; Saftig, Paul ; Grinstein S ; Dhe-Paganon S:
Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36 .
In: Nature (2013), Nr. 504, S. 172-176

Cohnen A ; Chiang SC ; Stojanovic A ; Schmidt H ; Claus M ; Saftig, Paul ; Janßen O ; Cerwenka A ; Bryceson YT ; Watzl C:
Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage .
In: Blood (2013), Nr. 122, S. 1411-1418

Bronckers AL ; Gueneli N ; Lüllmann-Rauch R ; Schneppenheim J ; Moraru AP ; Himmerkus N ; Bervoets TJ ; Fluhrer R ; Everts V ; Saftig, Paul ; Schröder B:
The intramembrane protease SPPL2A is critical for tooth enamel formation .
In: J Bone Miner Res (2013), Nr. 28, S. 1622-1630

Schneppenheim J ; Dressel R ; Hüttl S ; Lüllmann-Rauch R ; Engelke M ; Dittmann K ; Wienands J ; Eskelinen EL ; Hermans-Borgmeyer I ; Fluhrer R ; Saftig, Paul ; Schröder B:
The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain .
In: J Exp Med (2013), Nr. 210, S. 41-58

Kraft S ; Jouvin MH ; Kulkarni N ; Kissing S ; Morgan ES ; Dvorak AM ; Schröder B ; Saftig, Paul ; Kinet JP:
The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis .
In: J Immunol (2013), Nr. 191, S. 2871-2878

Zachos C ; Blanz J ; Saftig, Paul ; Schwake M:
A critical histidine residue within LIMP-2 mediates pH sensitive binding to its ligand ß-glucocerebrosidase. .
In: Traffic (2012), Nr. 13, S. 1113-1123

Suzuki K ; Hayashi Y ; Nakahara S ; Kumazaki H ; Prox J ; Horiuchi K ; Zeng M ; Tanimura S ; Nishiyama Y ; Osawa S ; Sehara-Fujisawa A ; Saftig, Paul ; Yokoshima S ; Fukuyama T ; Matsuki N ; Koyama R ; Tomita T ; Iwatsubo T:
Activity-dependent proteolytic cleavage of neuroligin-1 .
In: Neuron (2012), Nr. 76, S. 410-422

Tharmarajah G ; Faas L ; Reiss K ; Saftig, Paul ; Young A ; Van Raamsdonk CD:
Adam10 haploinsufficiency causes freckle-like macules in Hairless mice .
In: Pigment Cell Melanoma Res (2012), Nr. 25, S. 555-565

Weber S ; Saftig, Paul:
Ectodomain shedding and ADAMs in development .
In: Development (2012), Nr. 139, S. 3693-3709

Arampatzidou M ; Schütte A ; Hansson GC ; Saftig, Paul ; Brix K:
Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon .
In: Biol Chem (2012), Nr. 393, S. 1391-1403

Makrypidi G ; Damme, Markus ; Müller-Loennies S ; Trusch M ; Schmidt B ; Schlüter H ; Heeren J ; Lübke T ; Saftig, Paul ; Braulke T:
Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5 .
In: Mol Cell Biol (2012), Nr. 32, S. 774-782

Xu H ; Zhu J ; Smith S ; Foldi J ; Zhao B ; Chung AY ; Outtz H ; Kitajewski J ; Shi C ; Weber S ; Saftig, Paul ; Li Y ; Ozato K ; Blobel CP ; Ivashkiv LB ; Hu X:
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization .
In: Nat Immunol (2012), Nr. 13, S. 642-650

Prox J ; Rittger A ; Saftig, Paul:
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin .
In: Exp Brain Res (2012), Nr. 217, S. 331-341

Appelqvist H ; Sandin L ; Björnström K ; Saftig, Paul ; Garner B ; Ollinger K ; Kagedal K:
Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content .
In: PLoS One (2012), Nr. 7, S. e50262

Cai J ; Qi X ; Kociok N ; Skosyrski S ; Emilio A ; Ruan Q ; Han S ; Liu L ; Chen Z ; Bowes Rickman C ; Golde T ; Grant MB ; Saftig, Paul ; Serneels L ; De Strooper B ; Joussen AM ; Boulton ME:
ß-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment .
In: EMBO Mol Med (2012), Nr. 4, S. 980-991

Prox J ; Willenbrock M ; Weber S ; Lehmann T ; Schmidt-Arras D ; Schwanbeck R ; Saftig, Paul ; Schwake M:
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10 .
In: Cell Mol Life Sci (2012), Nr. 69, S. 2919-2932

Demirel Ö ; Jan I ; Wolters D ; Blanz J ; Saftig, Paul ; Tampé R ; Abele R:
The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2 .
In: J Cell Sci (2012), Nr. 125, S. 4230-4240

Cullen V ; Sardi SP ; Ng J ; Xu YH ; Sun Y ; Tomlinson JJ ; Kolodziej P ; Kahn I ; Saftig, Paul ; Woulfe J ; Rochet JC ; Glicksman MA ; Cheng SH ; Grabowski GA ; Shihabuddin LS ; Schlossmacher MG:
Acid ß-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter a-synuclein processing .
In: Ann Neurol (2011), Nr. 69, S. 940-953

Dauth S ; Sirbulescu RF ; Jordans S ; Rehders M ; Avena L ; Oswald J ; Lerchl A ; Saftig, Paul ; Brix K:
Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits .
In: BMC Neurosci (2011), Nr. 12, S. 74

Doyle EL ; Ridger V ; Ferraro F ; Turmaine M ; Saftig, Paul ; Cutler DF:
CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin .
In: Blood (2011), Nr. 118, S. 4265-4273

Damme, Markus ; Stroobants S ; Walkley SU ; Lüllmann-Rauch R ; D'Hooge R ; Fogh J ; Saftig, Paul ; Lübke T, Blanz J ; Blanz J:
Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in a-mannosidosis .
In: J Neuropathol Exp Neurol (2011), Nr. 70, S. 83-94

Glomski K ; Monette S ; Manova K ; De Strooper B ; Saftig, Paul ; Blobel CP:
Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures .
In: Blood (2011), Nr. 118, S. 1163-1174

Savalas LR ; Gasnier B ; Damme, Markus ; Lübke T ; Wrocklage C ; Debacker C ; Jézégou A ; Reinheckel T ; Hasilik A ; Saftig, Paul ; Schröder B:
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L .
In: Biochem J (2011), Nr. 439, S. 113-128

Altmeppen HC ; Prox J ; Puig B ; Kluth MA ; Bernreuther C ; Thurm D ; Jorissen E ; Petrowitz B ; Bartsch U ; De Strooper B ; Saftig, Paul ; Glatzel M:
Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo .
In: Mol Neurodegener (2011), Nr. 6, S. 36

Carrasco-Marín E ; Fernández-Prieto L ; Rodriguez-Del Rio E ; Madrazo-Toca F ; Reinheckel T ; Saftig, Paul ; Alvarez-Dominguez C:
LIMP-2 links late phagosomal trafficking with the onset of the innate immune response to Listeria monocytogenes: a role in macrophage activation .
In: J Biol Chem (2011), Nr. 286, S. 3332-3341

Evans SF ; Irmady K ; Ostrow K ; Kim T ; Nykjaer A ; Saftig, Paul ; Blobel C ; Hempstead BL:
Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation .
In: J Biol Chem (2011), Nr. 286, S. 29556-29567

Sulis ML ; Saftig, Paul ; Ferrando AA:
Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL .
In: Leukemia (2011), Nr. 25, S. 1564-1569

Schneede A ; Schmidt CK ; Hölttä-Vuori M ; Heeren J ; Willenborg M ; Blanz J ; Domanskyy M ; Breiden B ; Brodesser S ; Landgrebe J ; Sandhoff K ; Ikonen E ; Saftig, Paul ; Eskelinen EL:
Role for LAMP-2 in endosomal cholesterol transport .
In: J Cell Mol Med (2011), Nr. 15, S. 280-295

Behnke J ; Schneppenheim J ; Koch-Nolte F ; Haag F ; Saftig, Paul ; Schröder B:
Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail .
In: FEBS Lett (2011), Nr. 585, S. 2951-2957

Tamboli IY ; Hampel H ; Tien NT ; Tolksdorf K ; Breiden B ; Mathews PM ; Saftig, Paul ; Sandhoff K ; Walter J:
Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation .
In: J Neurosci (2011), Nr. 31, S. 1837-1849

Huth T ; Rittger A ; Saftig, Paul ; Alzheimer C:
ß-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel ß4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current .
In: Pflugers Arch (2011), Nr. 461, S. 355-371

Saftig, Paul ; Reiss K:
The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: novel drug targets with therapeutic potential?
In: Eur J Cell Biol (2011), Nr. 90, S. 527-535

Weber S ; Niessen MT ; Prox J ; Lüllmann-Rauch R ; Schmitz A ; Schwanbeck R ; Blobel CP ; Jorissen E ; de Strooper B ; Niessen CM ; Saftig, Paul:
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling .
In: Development (2011), Nr. 138, S. 495-505

Zhang D ; Leung N ; Weber E ; Saftig, Paul ; Brömme D:
The effect of cathepsin K deficiency on airway development and TGF-ß1 degradation .
In: Respir Res (2011), Nr. 12, S. 72

Rabe S ; Reichwald J ; Ammaturo D ; de Strooper B ; Saftig, Paul ; Neumann U ; Staufenbiel M:
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing .
In: J Neurochem (2011), Nr. 119, S. 231-239

van Niel G ; Charrin S ; Simoes S ; Romao M ; Rochin L ; Saftig, Paul ; Marks MS ; Rubinstein E ; Raposo G:
The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis .
In: Dev Cell (2011), Nr. 21, S. 708-721

Desmond MJ ; Lee D ; Fraser SA ; Katerelos M ; Gleich K ; Martinello P ; Li YQ ; Thomas MC ; Michelucci R ; Cole AJ ; Saftig, Paul ; Schwake M ; Stapleton D ; Berkovic SF ; Power DA:
Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2 .
In: Am J Physiol Renal Physiol (2011), Nr. 300, S. F1437-1447

Behnke J ; Eskelinen EL ; Saftig, Paul ; Schröder B:
Two dileucine motifs mediate late endosomal/lysosomal targeting of transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers .
In: Biochem J (2011), Nr. 434, S. 219-231

Kim J ; Lilliehook C ; Dudak A ; Prox J ; Saftig, Paul ; Federoff HJ ; Lim ST:
Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10) .
In: J Biol Chem (2010), Nr. 285, S. 22919-22926

Le Gall SM ; Maretzky T ; Issuree PD ; Niu XD ; Reiss K ; Saftig, Paul ; Khokha R ; Lundell D ; Blobel CP:
ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site .
In: J Cell Sci (2010), Nr. 123, S. 3913-3922

Ha, SD. ; Ham, B. ; Mogridge, J. ; Saftig, Paul ; Lin, S. ; Kim, SO.:
Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm. .
In: J Biol Chem. (2010), Nr. 285, S. 2120-2129

Bai L ; Beckers L ; Wijnands E ; Lutgens SP ; Herías MV ; Saftig, Paul ; Daemen MJ ; Cleutjens K ; Lutgens E ; Biessen EA ; Heeneman S:
Cathepsin K gene disruption does not affect murine aneurysm formation .
In: Atherosclerosis (2010), Nr. 209, S. 96-103

Arndt V ; Dick N ; Tawo R ; Dreiseidler M ; Wenzel D ; Hesse M ; Fürst DO ; Saftig, Paul ; Saint R ; Fleischmann BK ; Hoch M ; Höhfeld J:
Chaperone-assisted selective autophagy is essential for muscle maintenance .
In: Curr Biol (2010), Nr. 20, S. 143-148

Shevtsova Z ; Garrido M ; Weishaupt J ; Saftig, Paul ; Bähr M ; Lühder F ; Kügler S:
CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis .
In: Am J Pathol (2010), Nr. 177, S. 271-279

Chalaris-Rißmann, Athena ; Adam, N ; Sina, C ; Rosenstiel, P ; Lehmann-Koch, J ; Schirmacher, P ; Hartmann, D ; Cichy, J ; Gavrilova, O ; Schreiber, S ; Jostock, T ; Matthews, V ; Häsler, R ; Becker, C ; Neurath, MF ; Reiss, K ; Saftig, Paul ; Scheller, J ; Rose-John, Stefan:
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice .
In: J Exp Med (2010), Nr. 207, S. 1617-24

Blanz, Judith ; Groth, Johann ; Zachos, Christina ; Wehling, C. ; Saftig, Paul ; Schwake, Michael:
Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-glucocerebrosidase. .
In: Hum Mol Genet. (2010), Nr. 19, S. 563-572

Saftig, Paul ; Schröder B ; Blanz J:
Lysosomal membrane proteins: life between acid and neutral conditions .
In: Biochem Soc Trans (2010), Nr. 38, S. 1420-1423

Schröder B ; Wrocklage C ; Hasilik A ; Saftig, Paul:
Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane .
In: Biol Chem (2010), Nr. 391, S. 695-704

Schröder, Bernd ; Saftig, Paul:
Molecular insights into mechanisms of intramembrane proteolysis through signal peptide peptidase (SPP). .
In: Biochem J. (2010), Nr. 427, S. 523-534

Mendelson K ; Swendeman S ; Saftig, Paul ; Blobel CP:
Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways .
In: J Biol Chem (2010), Nr. 285, S. 25024-25032

Jorissen, E ; Prox, Johannes ; Bernreuther, C ; Weber, Silvio ; Schwanbeck, Ralf ; Serneels, L ; Snellinx, A ; Craessaerts, K ; Thathiah, A ; Tesseur, I ; Bartsch, U ; Weskamp, G ; Blobel, CP ; Glatzel, M ; De Strooper, B ; Saftig, Paul:
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. .
In: J. Neurosci. (2010), Nr. 30, S. 4833-4844

Schröder BA ; Wrocklage C ; Hasilik A ; Saftig, Paul:
The proteome of lysosomes .
In: Proteomics (2010), Nr. 10, S. 4053-4076

Tousseyn, T. ; Thathiah, A. ; Jorissen, E. ; Raemaekers, T. ; Konietzko, U. ; Reiß, Karina ; Maes, K.E. ; Snellinx, A. ; Serneels, L. ; Nyabi, O. ; Annaert, W. ; Weskamp, G. ; Blobel, C. ; Saftig, Paul ; Hartmann, D. ; de Strooper, B.:
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. .
In: J Biol Chem. (2009), Nr. 284, S. 11738-11747

Le Gall, S.M. ; Bobe, P. ; Reiß, Karina ; Horiuchi, K. ; Niu, X.D. ; Lundell, D. ; Gibb, D.R. ; Conrad, D. ; Saftig, Paul ; Blobel, C.P.:
ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha. .
In: Mol Biol Cell. (2009), Nr. 20, S. 1785-1794

Hata, S ; Fujishige, S ; Araki, Y ; Kato, N ; Araseki, M ; Nishimura, M ; Hartmann, D ; Saftig, Paul ; Fahrenholz, F ; Taniguchi, M ; Urakami, K ; Akatsu, H ; Martin, RN ; Yamamoto, K ; Maeda, M ; Yamamoto, T ; Nakaya, T ; Gandy, S ; Suzuki, T:
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. .
In: J Biol Chem. (2009), Nr. 284, S. 36024-36033

Saftig, Paul ; Eskelinen, EL.:
Autophagy: a lysosomal degradation pathway with a central role in health and disease. .
In: Biochim Biophys Acta. (2009), Nr. 1793, S. 664-673

Pennypacker, B ; Shea, M ; Liu, Q ; Masarachia, P ; Saftig, Paul ; Rodan, S ; Rodan, G ; Kimmel, D:
Bone density, strength, and formation in adult cathepsin K (-/-) mice. .
In: Bone (2009), Nr. 44, S. 199-207

Cullen, V. ; Lindfors, M. ; Ng, J. ; Paetau, A. ; Swinton, E. ; Kolodzeij, P. ; Boston, H. ; Saftig, Paul ; Woulfe, J. ; Feany, M.B. ; Myllykangas, L. ; Schlossmacher, M.G. ; Tyynelä, J.:
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo. .
In: Mol Brain. (2009), Nr. 2, S. 5

Cruz-Soto, M. ; Cosio, G. ; Jeziorski, M.C. ; Vargas, V. ; Aguilar, M. ; Carabez, A. ; Berger, P. ; Saftig, Paul ; Thebault, S. ; de la Escalera, G.M. ; Clapp, C.:
Cathepsin D is the primary protease for the generation of adenohypophyseal vasoinhibins: cleavage occurs within the prolactin secretory granules. .
In: Endocrinology. (2009), Nr. 150, S. 5446-5454

Wilson, SR ; Peters, C ; Saftig, Paul ; Brömme, D:
Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. .
In: J Biol Chem. (2009), Nr. 284, S. 2584-2592

Janes, P. ; Wimmer-Kleikamp, S. ; Frangakis, A. ; Treble, K. ; Griesshaber, B. ; Sabet, O. ; Grabenbauer, M. ; Ting, A. ; Saftig, Paul ; Bastiaens, P. ; Lackmann, M.:
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10. .
In: PLoS Biol. (2009), Nr. 7, S. e1000215

Schröder, J. ; Lülmann-Rauch, R. ; Himmerkus, N. ; Pleines, I. ; Nieswandt, B. ; Orinska, Z. ; Koch-Nolte, F. ; Schröder, Bernd ; Bleich, M. ; Saftig, Paul:
Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function. .
In: Mol Cell Biol. (2009), Nr. 29, S. 1083-1094

Wilson, S. ; Hashamiyan, S. ; Clarke, L. ; Saftig, Paul ; Mort, J. ; Dejica, V.M. ; Brömme, D.:
Glycosaminoglycan-mediated loss of cathepsin K collagenolytic activity in MPS I contributes to osteoclast and growth plate abnormalities. .
In: Am J Pathol. (2009), Nr. 175, S. 2053-2062

Bloch, L. ; Sineshchekova, O. ; Reichenbach, D. ; Reiß, Karina ; Saftig, Paul ; Kuro-o, M. ; Kaether, C.:
Klotho is a substrate for alpha-, beta- and gamma-secretase. .
In: FEBS Lett. (2009), Nr. 583, S. 3221-3224

Saftig, Paul ; Klumpermann, J:
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. .
In: Nat Rev Mol Cell Biol. (2009), Nr. 10, S. 623-635

Huth, T ; Schmidt-Neuenfeldt, K ; Rittger, Andrea ; Saftig, Paul ; Reiß, Karina ; Alzheimer, C:
Non-proteolytic effect of beta-site APP-cleaving enzyme 1 (BACE1) on sodium channel function. .
In: Neurobiol Dis (2009), Nr. 33, S. 282-289

Annaert, WG ; Saftig, Paul:
Regulated intramembrane proteolysis--a story about sheddases and I-CliPs. .
In: Semin Cell Dev Biol. (2009), Nr. 20, S. 125-125

Reiß, Karina ; Saftig, Paul:
The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions. .
In: Semin Cell Dev Biol. (2009), Nr. 20, S. 126-137

Raucci A ; Cugusi S ; Antonelli A ; Barabino SM ; Monti L ; Bierhaus A ; Reiss K ; Saftig, Paul ; Bianchi ME:
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10) .
In: FASEB J (2008), Nr. 22, S. 3716-3727

Jabs, S. ; Quitsch, A. ; Käkelä, R. ; Koch, B. ; Tyynelä, J. ; Brade, H. ; Glatzel, M. ; Walkley, S. ; Saftig, Paul ; Vanier, MT. ; Braulke, T.:
Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis. .
In: J Neurochem. (2008), Nr. 106, S. 1415-1425

Schulz, B. ; Prüssmeyer, J. ; Maretzky, T. ; Ludwig, A. ; Blobel, CP. ; Saftig, Paul ; Reiß, Karina:
ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin. .
In: Circ Res. (2008), Nr. 102, S. 1192-1201

Maretzky, T. ; Scholz, F. ; Köten, B. ; Proksch, E. ; Saftig, Paul ; Reiß, Karina:
ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis. .
In: J Invest Dermatol. (2008), Nr. 128, S. 1737-1746

Berkovic, SF. ; Dibbnes, LM. ; Oshlack, A. ; Silver, JD. ; Katerelos, M. ; Vears, DF. ; Lüllmann-Rauch, Renate ; Blanz, Judith ; Zhang, KW. ; Stankovich, J. ; Kalnins, RM. ; Dowling, JP. ; Andermann, E. ; Andermann, F. ; Faldini, E. ; D´Hooge, R. ; Vadlamudi, L. ; Macdonell, RA. ; Hodgson, BL. ; Bayly, MA. ; Savige, J. ; Mulley, JC. ; Smyth, GK. ; Power, DA. ; Saftig, Paul ; Bahlo, M.:
Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis. .
In: Am J Hum Genet. (2008), Nr. 82, S. 673-684

Schurigt, U. ; Hummel, KM. ; Petrow, PK. ; Gajda, M. ; Stöckigt, R. ; Middel, P. ; Zwerina, J. ; Janik, T. ; Bernhardt, R. ; Schüler, S. ; Scharnweber, D. ; Beckmann, F. ; Saftig, Paul ; Kollias, G. ; Schett, G. ; Wiederanders, B. ; Bräuer, R.:
Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice. .
In: Arthritis Rheum. (2008), Nr. 58, S. 422-434

Asagiri, M. ; Hirai, T. ; Kunigami, T. ; Kamano, S. ; Gober, H-J. ; Okamoto, K. ; Nishikawa, K. ; Latz, E. ; Golenbock, DT. ; Aoki, K. ; Ohya, K. ; Imai, K. ; Morishita, Y. ; Miyazono, K. ; Kato, S. ; Saftig, Paul ; Takayanagi, H.:
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. .
In: Science. (2008), Nr. 319, S. 624-627

Beertsen, W. ; Willenborg, M. ; Everts, V. ; Zirogianni, A. ; Podschun, R. ; Schröder, Bernd ; Eskelinen, EL. ; Saftig, Paul:
Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice. .
In: J Immunol. (2008), Nr. 180, S. 475-482

Saftig, Paul ; Beertsen, W. ; Eskelinen, EL.:
LAMP-2: a control step for phagosome and autophagosome maturation. .
In: Autophagy (2008), Nr. 4, S. 510-512

Saftig, Paul ; Eskelinen, EL.:
Live longer with LAMP-2. .
In: Nat Med. (2008), Nr. 14, S. 909-910

Malicdan MC ; Noguchi S ; Nonaka I ; Saftig, Paul ; Nishino I:
Lysosomal myopathies: an excessive build-up in autophagosomes is too much to handle .
In: Neuromuscul Disord (2008), Nr. 18, S. 521-529

Martin L ; Fluhrer R ; Reiss K ; Kremmer E ; Saftig, Paul ; Haass C:
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b .
In: J Biol Chem (2008), Nr. 283, S. 1644-1652

Blanz J ; Stroobants S ; Lüllmann-Rauch R ; Morelle W ; Lüdemann M ; D'Hooge R ; Reuterwall H ; Michalski JC ; Fogh J ; Andersson C ; Saftig, Paul:
Reversal of peripheral and central neural storage and ataxia after recombinant enzyme replacement therapy in alpha-mannosidosis mice .
In: Hum Mol Genet (2008), Nr. 17, S. 3437-3445

Samokhin, AO. ; Wong, A. ; Saftig, Paul ; Brömme, D.:
Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice. .
In: Atherosclerosis (2008), Nr. 200, S. 58-68

Partanen, S. ; Haapanen, A. ; Kielar, C. ; Pontikis, C. ; Alexander, N. ; Inkinen, T. ; Saftig, Paul ; Gillingwater, TH. ; Cooper, JD. ; Tyynelä J.:
Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis. .
In: J Neuropathol Exp Neurol. (2008), Nr. 67, S. 16-29

Eichenauer DA ; Simhadri VL ; von Strandmann EP ; Ludwig A ; Matthews V ; Reiners KS ; von Tresckow B ; Saftig, Paul ; Rose-John S ; Engert A ; Hansen HP:
ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro .
In: Cancer Res (2007), Nr. 67, S. 332-338

Schulte M ; Reiss K ; Lettau M ; Maretzky T ; Ludwig A ; Hartmann D ; de Strooper B ; Janssen O ; Saftig, Paul:
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death .
In: Cell Death Differ (2007), Nr. 14, S. 1040-1049

Walls KC ; Klocke BJ ; Saftig, Paul ; Shibata M ; Uchiyama Y ; Roth KA ; Shacka JJ:
Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain .
In: Autophagy (2007), Nr. 3, S. 222-229

Binker MG ; Cosen-Binker LI ; Terebiznik MR ; Mallo GV ; McCaw SE ; Eskelinen EL ; Willenborg M ; Brumell JH ; Saftig, Paul ; Grinstein S ; Gray-Owen SD:
Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2 .
In: Cell Microbiol (2007), Nr. 9, S. 2153-2166

Shacka JJ ; Klocke BJ ; Young C ; Shibata M ; Olney JW ; Uchiyama Y ; Saftig, Paul ; Roth KA:
Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis .
In: J Neurosci (2007), Nr. 27, S. 2081-2090

Funicello M ; Novelli M ; Ragni M ; Vottari T ; Cocuzza C ; Soriano-Lopez J ; Chiellini C ; Boschi F ; Marzola P ; Masiello P ; Saftig, Paul ; Santini F ; St-Jacques R ; Desmarais S ; Morin N ; Mancini J ; Percival MD ; Pinchera A ; Maffei M:
Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores .
In: PLoS One (2007), Nr. 2, S. e683

Eichenauer, DA. ; Simhadri, VL. ; Pogge von Strandmann, E. ; Ludwig, Andrea ; Matthews, V. ; von Tresckow, B. ; Saftig, Paul ; Rose-John, Stefan ; Engert, A. ; Hansen, HP.:
CD30 targeting of lymphoma cells is misdirected by ADAM10-dependent antigen migration to CD30 ligand-expressing non-target cells. .
In: Cancer Res. (2007), Nr. 67, S. 332-338

Tulone C ; Uchiyama Y ; Novelli M ; Grosvenor N ; Saftig, Paul ; Chain BM:
Haematopoietic development and immunological function in the absence of cathepsin D .
In: BMC Immunol (2007), Nr. 8, S. 22

Yamasaki R ; Zhang J ; Koshiishi I ; Sastradipura Suniarti DF ; Wu Z ; Peters C ; Schwake M ; Uchiyama Y ; Kira J ; Saftig, Paul ; Utsumi H ; Nakanishi H:
Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice .
In: Mol Cell Neurosci (2007), Nr. 35, S. 573-584

Huynh KK ; Eskelinen EL ; Scott CC ; Malevanets A ; Saftig, Paul ; Grinstein S:
LAMP proteins are required for fusion of lysosomes with phagosomes .
In: EMBO J (2007), Nr. 26, S. 313-324

Reczek D ; Schwake M ; Schröder J ; Hughes H ; Blanz J ; Jin X ; Brondyk W ; Van Patten S ; Edmunds T ; Saftig, Paul:
LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase .
In: Cell (2007), Nr. 131, S. 770-783

Schroen B ; Leenders JJ ; van Erk A ; Bertrand AT ; van Loon M ; van Leeuwen RE ; Kubben N ; Duisters RF ; Schellings MW ; Janssen BJ ; Debets JJ ; Schwake M ; Høydal MA ; Heymans S ; Saftig, Paul ; Pinto YM:
Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy .
In: J Exp Med (2007), Nr. 204, S. 1227-1235

Li N ; Wang Y ; Forbes K ; Vignali KM ; Heale BS ; Saftig, Paul ; Hartmann D ; Black RA ; Rossi JJ ; Blobel CP ; Dempsey PJ ; Workman CJ ; Vignali DA:
Metalloproteases regulate T-cell proliferation and effector function via LAG-3 .
In: EMBO J (2007), Nr. 26, S. 494-504

Hundhausen C ; Schulte A ; Schulz B ; Andrzejewski MG ; Schwarz, Nadine ; von Hundelshausen P ; Winter U ; Paliga K ; Reiss K. ; Saftig, Paul ; Weber C ; Ludwig A:
Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes .
In: J Immunol (2007), Nr. 178, S. 8064-8072

Wehling, Christina ; Beimgraben, C. ; Gelhaus, C. ; Friedrich, T. ; Saftig, Paul ; Grötzinger, Joachim ; Schwake, Michael:
Self-Assembly of the isolated KCNQ2 subunit interaction domain .
In: FEBS J (2007), Nr. 581, S. 1594-1598

Horiuchi K ; Le Gall S ; Schulte M ; Yamaguchi T ; Reiss K ; Murphy G ; Toyama Y ; Hartmann D ; Saftig, Paul ; Blobel CP:
Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx .
In: Mol Biol Cell (2007), Nr. 18, S. 176-188

Apetoh L ; Ghiringhelli FL ; Tesniere A ; Obeid M ; Ortiz C ; Criollo A ; Mignot G ; Maiuri MC ; Ullrich E ; Saulnier P ; Yang H ; Amigorena S ; Ryffel B ; Barrat FJ ; Saftig, Paul ; Levi F ; Lidereau R ; Nogues C ; Mira JP ; Chompret A ; Joulin V ; Clavel-Chapelon F ; Bourhis J ; André F ; Delaloge S ; Tursz T ; Kroemer G ; Zitvogel L:
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy .
In: Nat Med (2007), Nr. 13, S. 1050-1059

Weskamp G ; Ford JW ; Sturgill J ; Martin S ; Docherty AJ ; Swendeman S ; Broadway N ; Hartmann D ; Saftig, Paul ; Umland S ; Sehara-Fujisawa A ; Black RA ; Ludwig A ; Becherer JD ; Conrad DH ; Blobel CP:
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23 .
In: Nat Immunol (2006), Nr. 7, S. 1293-1298

Reiss K ; Ludwig A ; Saftig, Paul:
Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion .
In: Pharmacol Ther (2006), Nr. 111, S. 985-1006

Perez-Amodio S ; Jansen DC ; Schoenmaker T ; Vogels IM ; Reinheckel T ; Hayman AR ; Cox TM ; Saftig, Paul ; Beertsen W ; Everts V:
Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity .
In: Calcif Tissue Int (2006), Nr. 79, S. 245-254

Steinfeld R ; Reinhardt K ; Schreiber K ; Hillebrand M ; Kraetzner R ; Bruck W ; Saftig, Paul ; Gartner J:
Cathepsin D deficiency is associated with a human neurodegenerative disorder .
In: Am J Hum Genet (2006), Nr. 78, S. 988-998

Röcken C ; Fändrich M ; Stix B ; Tannert A ; Hortschansky P ; Reinheckel T ; Saftig, Paul ; Kähne T ; Menard R ; Ancsin JB ; Bühling F:
Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis .
In: J Pathol (2006), Nr. 210, S. 478-487

Willem M ; Garratt AN ; Novak B ; Citron M ; Kaufmann S ; Rittger A ; DeStrooper B ; Saftig, Paul ; Birchmeier C ; Haass C:
Control of peripheral nerve myelination by the beta-secretase BACE1 .
In: Science (2006), Nr. 314, S. 664-666

del Cerro-Vadillo E ; Madrazo-Toca F ; Carrasco-Marín E ; Fernandez-Prieto L ; Beck C ; Leyva-Cobián F ; Saftig, Paul ; Alvarez-Dominguez C:
Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth .
In: J Immunol (2006), Nr. 176, S. 1321-1325

Knipper M ; Claussen C ; Rüttiger L ; Zimmermann U ; Lüllmann-Rauch R ; Eskelinen EL ; Schröder J ; Schwake M ; Saftig, Paul:
Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis .
In: J Physiol (2006), Nr. 576, S. 73-86

Lutgens E ; Lutgens SP ; Faber BC ; Heeneman S ; Gijbels MM ; de Winther MP ; Frederik P ; van der Made I ; Daugherty A ; Sijbers AM ; Fisher A ; Long CJ ; Saftig, Paul ; Black D ; Daemen MJ ; Cleutjens KB:
Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation .
In: Circulation (2006), Nr. 113, S. 98-107

Anders L ; Mertins P ; Lammich S ; Murgia M ; Hartmann D ; Saftig, Paul ; Haass C ; Ullrich A:
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity .
In: Mol Cell Biol (2006), Nr. 26, S. 3917-3934

Lutgens SP ; Kisters N ; Lutgens E ; van Haaften RI ; Evelo CT ; Winther MP ; Saftig, Paul ; Daemen MJ ; Heeneman S ; Cleutjens KB:
Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic .
In: J Pathol (2006), Nr. 210, S. 334-343

Stypmann J ; Janssen PM ; Prestle J ; Engelen MA ; Kögler H ; Lüllmann-Rauch R ; Eckardt L ; von Figura K ; Landgrebe J ; Mleczko A ; Saftig, Paul:
LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling .
In: Basic Res Cardiol (2006), Nr. 101, S. 281-291

Caeyenberghs K ; Balschun D ; Roces DP ; Schwake M ; Saftig, Paul ; D'Hooge R:
Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment .
In: Neurobiol Dis (2006), Nr. 23, S. 422-432

Everts V ; Korper W ; Hoeben KA ; Jansen ID ; Bromme D ; Cleutjens KB ; Heeneman S ; Peters C ; Reinheckel T ; Saftig, Paul ; Beertsen W:
Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone .
In: J Bone Miner Res (2006), Nr. 21, S. 1399-1408

Bech-Serra JJ ; Santiago-Josefat B ; Esselens C ; Saftig, Paul ; Baselga J ; Arribas J ; Canals F:
Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis .
In: Mol Cell Biol (2006), Nr. 26, S. 5086-5095

Reiss K ; Maretzky T ; Haas IG ; Schulte M ; Ludwig A ; Frank M ; Saftig, Paul:
Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion .
In: J Biol Chem (2006), Nr. 281, S. 21735-21744

Schwake M ; Athanasiadu D ; Beimgraben C ; Blanz J ; Beck C ; Jentsch TJ ; Saftig, Paul ; Friedrich T:
Structural determinants of M-type KCNQ (Kv7) K+ channel assembly .
In: J Neurosci (2006), Nr. 26, S. 3757-3766

Henningsson F ; Yamamoto K ; Saftig, Paul ; Reinheckel T ; Peters C ; Knight SD ; Pejler G:
A role for cathepsin E in the processing of mast-cell carboxypeptidase A .
In: J Cell Sci (2005), Nr. 118, S. 2035-2042

Reiss K ; Maretzky T ; Ludwig A ; Tousseyn T ; de Strooper B ; Hartmann D ; Saftig, Paul:
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling .
In: EMBO J (2005), Nr. 24, S. 742-752

Maretzky T ; Reiss K ; Ludwig A ; Buchholz J ; Scholz F ; Proksch E ; de Strooper B ; Hartmann D ; Saftig, Paul:
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation .
In: Proc Natl Acad Sci U S A (2005), Nr. 102, S. 9182-9187

Sugie K ; Noguchi S ; Kozuka Y ; Arikawa-Hirasawa E ; Tanaka M ; Yan C ; Saftig, Paul ; von Figura K ; Hirano M ; Ueno S ; Nonaka I ; Nishino I:
Autophagic vacuoles with sarcolemmal features delineate Danon disease and related myopathies .
In: J Neuropathol Exp Neurol (2005), Nr. 64, S. 513-522

Wong HK ; Sakurai T ; Oyama F ; Kaneko K ; Wada K ; Miyazaki H ; Kurosawa M ; De Strooper B ; Saftig, Paul ; Nukina N:
beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase .
In: J Biol Chem (2005), Nr. 280, S. 23009-23017

Maretzky, T. ; Schulte, Jan Markus ; Ludwig, Andrea ; Rose-John, Stefan ; Blobel, C. ; Hartmann, D. ; Altevogt, P. ; Saftig, Paul ; Reiß, Karina:
L1 is sequentially processed by two differently activatedmetalloproteases and presenilin/g-secretase regulating neural celladhesion, cell migration and neurite outgrowth. .
In: Mol. Cell Biol. (2005), Nr. 25, S. 9040-9053

Willenborg M ; Schmidt CK ; Braun P ; Landgrebe J ; von Figura K ; Saftig, Paul ; Eskelinen EL:
Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation .
In: J Lipid Res (2005), Nr. 46, S. 2559-2569

Schenzer, A. ; Friedrich, T. ; Pusch, M. ; Saftig, Paul ; Jentsch, TJ. ; Grötzinger, Joachim ; Schwake, Michael:
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine .
In: J. Neuro sci (2005), Nr. 25, S. 5051-5060

D'Hooge R ; Lüllmann-Rauch R ; Beckers T ; Balschun D ; Schwake M ; Reiss K ; von Figura K ; Saftig, Paul:
Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis .
In: J Neurosci (2005), Nr. 25, S. 6539-6549

Koike M ; Shibata M ; Waguri S ; Yoshimura K ; Tanida I ; Kominami E ; Gotow T ; Peters C ; von Figura K ; Mizushima N ; Saftig, Paul ; Uchiyama Y:
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease) .
In: Am J Pathol (2005), Nr. 167, S. 1713-1728

Dominguez D ; Tournoy J ; Hartmann D ; Huth T ; Cryns K ; Deforce S ; Serneels L ; Camacho IE ; Marjaux E ; Craessaerts K ; Roebroek AJ ; Schwake M ; D'Hooge R ; Bach P ; Kalinke U ; Moechars D ; Alzheimer C ; Reiss K ; Saftig, Paul ; De Strooper B:
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice .
In: J Biol Chem (2005), Nr. 280, S. 30797-30806

Shimizu T ; Hayashi Y ; Yamasaki R ; Yamada J ; Zhang J ; Ukai K ; Koike M ; Mine K ; von Figura K ; Peters C ; Saftig, Paul ; Fukuda T ; Uchiyama Y ; Nakanishi H:
Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice .
In: J Neurochem (2005), Nr. 94, S. 680-690

Budagian V ; Bulanova E ; Orinska Z ; Duitman E ; Brandt K ; Ludwig A ; Hartmann D ; Lemke G ; Saftig, Paul ; Bulfone-Paus S:
Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum .
In: Mol Cell Biol (2005), Nr. 25, S. 9324-9339

González-Polo RA ; Boya P ; Pauleau AL ; Jalil A ; Larochette N ; Souquère S ; Eskelinen EL ; Pierron G ; Saftig, Paul ; Kroemer G:
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death .
In: J Cell Sci (2005), Nr. 118, S. 3091-3102

Kuronita T ; Hatano T ; Furuyama A ; Hirota Y ; Masuyama N ; Saftig, Paul ; Himeno M ; Fujita H ; Tanaka Y:
The NH(2)-terminal transmembrane and lumenal domains of LGP85 are needed for the formation of enlarged endosomes/lysosomes .
In: Traffic (2005), Nr. 6, S. 895-906

Eskelinen EL ; Cuervo AM ; Taylor MR ; Nishino I ; Blum JS ; Dice JF ; Sandoval IV ; Lippincott-Schwartz J ; August JT ; Saftig, Paul:
Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2 .
In: Traffic (2005), Nr. 6, S. 1058-1061

Kilb W ; Hartmann D ; Saftig, Paul ; Luhmann HJ:
Altered morphological and electrophysiological properties of Cajal-Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout mice .
In: Eur J Neurosci (2004), Nr. 20, S. 2749-2756

Egberts F ; Heinrich M ; Jensen JM ; Winoto-Morbach S ; Pfeiffer S ; Wickel M ; Schunck M ; Steude J ; Saftig, Paul ; Proksch E ; Schütze S:
Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation .
In: J Cell Sci (2004), Nr. 117, S. 2295-2307

Hausmann M ; Obermeier F ; Schreiter K ; Spottl T ; Falk W ; Schölmerich J ; Herfarth H ; Saftig, Paul ; Rogler G:
Cathepsin D is up-regulated in inflammatory bowel disease macrophages .
In: Clin Exp Immunol (2004), Nr. 136, S. 157-167

Godat E ; Lecaille F ; Desmazes C ; Duchêne S ; Weidauer E ; Saftig, Paul ; Brömme D ; Vandier C ; Lalmanach G:
Cathepsin K: a cysteine protease with unique kinin-degrading properties .
In: Biochem J (2004), Nr. 383, S. 501-506

Wille A ; Gerber A ; Heimburg A ; Reisenauer A ; Peters C ; Saftig, Paul ; Reinheckel T ; Welte T ; Bühling F:
Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells .
In: Biol Chem (2004), Nr. 385, S. 665-670

Nagano O ; Murakami D ; Hartmann D ; De Strooper B ; Saftig, Paul ; Iwatsubo T ; Nakajima M ; Shinohara M ; Saya H:
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation .
In: J Cell Biol (2004), Nr. 165, S. 893-902

Westmeyer GG ; Willem M ; Lichtenthaler SF ; Lurman G ; Multhaup G ; Assfalg-Machleidt I ; Reiss K ; Saftig, Paul ; Haass C:
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme .
In: J Biol Chem (2004), Nr. 279, S. 53205-53212

Sahin U ; Weskamp G ; Kelly K ; Zhou HM ; Higashiyama S ; Peschon J ; Hartmann D ; Saftig, Paul ; Blobel CP:
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands .
In: J Cell Biol (2004), Nr. 164, S. 769-779

Eskelinen EL ; Schmidt CK ; Neu S ; Willenborg M ; Fuertes G ; Salvador N ; Tanaka Y ; Lüllmann-Rauch R ; Hartmann D ; Heeren J ; von Figura K ; Knecht E ; Saftig, Paul:
Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts .
In: Mol Biol Cell (2004), Nr. 15, S. 3132-3145

Roces DP ; Lüllmann-Rauch R ; Peng J ; Balducci C ; Andersson C ; Tollersrud O ; Fogh J ; Orlacchio A ; Beccari T ; Saftig, Paul ; von Figura K:
Efficacy of enzyme replacement therapy in alpha-mannosidosis mice: a preclinical animal study .
In: Hum Mol Genet (2004), Nr. 13, S. 1979-1988

Zheng Y ; Saftig, Paul ; Hartmann D ; Blobel C:
Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17) .
In: J Biol Chem (2004), Nr. 279, S. 42898-42906

Weskamp G ; Schlöndorff J ; Lum L ; Becherer JD ; Kim TW ; Saftig, Paul ; Hartmann D ; Murphy G ; Blobel CP:
Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR) .
In: J Biol Chem (2004), Nr. 279, S. 4241-4249

Budagian, V. ; Bulanova, E. ; Orinska, Zane ; Ludwig, A. ; Rose-John, Stefan ; Saftig, Paul ; Borden EC. ; Bulfone-Paus, Silvia:
Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) .
In: J. Biol. Chem. (2004), Nr. 279, S. 40368-40375

Tournoy J ; Bossuyt X ; Snellinx A ; Regent M ; Garmyn M ; Serneels L ; Saftig, Paul ; Craessaerts K ; De Strooper B ; Hartmann D:
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice .
In: Hum Mol Genet (2004), Nr. 13, S. 1321-1331

Bühling F ; Röcken C ; Brasch F ; Hartig R ; Yasuda Y ; Saftig, Paul ; Brömme D ; Welte T:
Pivotal role of cathepsin K in lung fibrosis .
In: Am J Pathol (2004), Nr. 164, S. 2203-2216

Esselens C ; Oorschot V ; Baert V ; Raemaekers T ; Spittaels K ; Serneels L ; Zheng H ; Saftig, Paul ; de Strooper B ; Klumperman J ; Annaert W:
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway .
In: J Cell Biol (2004), Nr. 166, S. 1041-1054

Jäger S ; Bucci C ; Tanida I ; Ueno T ; Kominami E ; Saftig, Paul ; Eskelinen EL:
Role for Rab7 in maturation of late autophagic vacuoles .
In: J Cell Sci (2004), Nr. 117, S. 4837-4848

Abel, S. ; Hundhausen, C. ; Mentlein, Rolf ; Schulte A ; Berkhout TA ; Broadway N ; Hartmann D ; Sedlacek R ; Dietrich S ; Muetze B ; Schuster B ; Kallen KJ ; Saftig, Paul ; Rose-John, Stefan ; Ludwig, Andrea:
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10 .
In: J. Immunol. (2004), Nr. 172, S. 6362–6372

Eskelinen EL ; Tanaka Y ; Saftig, Paul:
At the acidic edge: emerging functions for lysosomal membrane proteins .
In: Trends Cell Biol (2003), Nr. 13, S. 137-145

Everts V ; Hou WS ; Rialland X ; Tigchelaar W ; Saftig, Paul ; Brömme D ; Gelb BD ; Beertsen W:
Cathepsin K deficiency in pycnodysostosis results in accumulation of non-digested phagocytosed collagen in fibroblasts .
In: Calcif Tissue Int (2003), Nr. 73, S. 380-386

Matthews, V. ; Schuster, Björn ; Schütze, S. ; Bussmeyer, I. ; Ludwig, Andrea ; Hundhausen, Christoph ; Sadowski, T. ; Saftig, Paul ; Hartmann, D. ; Kallen, K-J. ; Rose-John, Stefan:
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). .
In: J. Biol. Chem. (2003), Nr. 278, S. 38829-38839

Schellens JP ; Saftig, Paul ; von Figura K ; Everts V:
Deficiency of mannose 6-phosphate receptors and lysosomal storage: a morphometric analysis of hepatocytes of neonatal mice .
In: Cell Biol Int (2003), Nr. 27, S. 897-902

Koike M ; Shibata M ; Ohsawa Y ; Nakanishi H ; Koga T ; Kametaka S ; Waguri S ; Momoi T ; Kominami E ; Peters C ; Figura Kv ; Saftig, Paul ; Uchiyama Y:
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice .
In: Mol Cell Neurosci (2003), Nr. 22, S. 146-161

Gamp AC ; Tanaka Y ; Lüllmann-Rauch R ; Wittke D ; D'Hooge R ; De Deyn PP ; Moser T ; Maier H ; Hartmann D ; Reiss K ; Illert AL ; von Figura K ; Saftig, Paul:
LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice .
In: Hum Mol Genet (2003), Nr. 12, S. 631-646

Lichtenthaler SF ; Dominguez DI ; Westmeyer GG ; Reiß, Karina ; Haass C ; Saftig, Paul ; De Strooper B ; Seed B:
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1 .
In: J Biol Chem (2003), Nr. 278, S. 48713-48719

Hundhausen, C. ; Misztela, D. ; Berkhout, TA. ; Broadway, N. ; Saftig, Paul ; Reiss, K. ; Hartmann, D. ; Fahrenholz, F. ; Postina, R. ; Matthews, V. ; Kallen, K-J. ; Rose-John, Stefan ; Ludwig, Andrea:
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion .
In: Blood (2003), Nr. 102, S. 1186-1195

Friedrichs B ; Tepel C ; Reinheckel T ; Deussing J ; von Figura K ; Herzog V ; Peters C ; Saftig, Paul ; Brix K:
Thyroid functions of mouse cathepsins B, K, and L .
In: J Clin Invest (2003), Nr. 111, S. 1733-1745

Leissring MA ; Murphy MP ; Mead TR ; Akbari Y ; Sugarman MC ; Jannatipour M ; Anliker B ; Müller U ; Saftig, Paul ; De Strooper B ; Wolfe MS ; Golde TE ; LaFerla FM:
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP .
In: Proc Natl Acad Sci U S A (2002), Nr. 99, S. 4697-4702

Kuronita T ; Eskelinen EL ; Fujita H ; Saftig, Paul ; Himeno M ; Tanaka Y:
A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology .
In: J Cell Sci (2002), Nr. 115, S. 4117-4131

Zwad O ; Kübler B ; Roth W ; Scharf JG ; Saftig, Paul ; Peters C ; Braulke T:
Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts .
In: FEBS Lett (2002), Nr. 510, S. 211-215

Nishioku T ; Hashimoto K ; Yamashita K ; Liou SY ; Kagamiishi Y ; Maegawa H ; Katsube N ; Peters C ; von Figura K ; Saftig, Paul ; Katunuma N ; Yamamoto K ; Nakanishi H:
Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia .
In: J Biol Chem (2002), Nr. 277, S. 4816-4822

Nyabi O ; Pype S ; Mercken M ; Herreman A ; Saftig, Paul ; Craessaerts K ; Serneels L ; Annaert W ; De Strooper B:
No endogenous A beta production in presenilin-deficient fibroblasts .
In: Nat Cell Biol (2002), Nr. 4, S. E164

Schürmann A ; Koling S ; Jacobs S ; Saftig, Paul ; Krauss S ; Wennemuth G ; Kluge R ; Joost HG:
Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene .
In: Mol Cell Biol (2002), Nr. 22, S. 2761-2768

Eskelinen EL ; Illert AL ; Tanaka Y ; Schwarzmann G ; Blanz J ; Von Figura K ; Saftig, Paul:
Role of LAMP-2 in lysosome biogenesis and autophagy .
In: Mol Biol Cell (2002), Nr. 13, S. 3355-3368

Everts V ; Delaissé JM ; Korper W ; Jansen DC ; Tigchelaar-Gutter W ; Saftig, Paul ; Beertsen W:
The bone lining cell: its role in cleaning Howship's lacunae and initiating bone formation .
In: J Bone Miner Res (2002), Nr. 17, S. 77-90

Hartmann D ; de Strooper B ; Serneels L ; Craessaerts K ; Herreman A ; Annaert W ; Umans L ; Lübke T ; Lena Illert A ; von Figura K ; Saftig, Paul:
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts .
In: Hum Mol Genet (2002), Nr. 11, S. 2615-2624

Jansen SM ; Groener JE ; Bax W ; Suter A ; Saftig, Paul ; Somerharju P ; Poorthuis BJ:
Biosynthesis of phosphatidylcholine from a phosphocholine precursor pool derived from the late endosomal/lysosomal degradation of sphingomyelin .
In: J Biol Chem (2001), Nr. 276, S. 18722-18727

Saftig, Paul ; Tanaka ; Lüllmann-Rauch R ; von Figura K:
Disease model: LAMP-2 enlightens Danon disease .
In: Trends Mol Med (2001), Nr. 7, S. 37-39

Wiltfang J ; Esselmann H ; Cupers P ; Neumann M ; Kretzschmar H ; Beyermann M ; Schleuder D ; Jahn H ; Rüther E ; Kornhuber J ; Annaert W ; De Strooper B ; Saftig, Paul:
Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells .
In: J Biol Chem (2001), Nr. 276, S. 42645-42657

Hartmann D ; Tournoy J ; Saftig, Paul ; Annaert W ; De Strooper B:
Implication of APP secretases in notch signaling .
In: J Mol Neurosci (2001), Nr. 17, S. 171-181

Nakanishi H ; Zhang J ; Koike M ; Nishioku T ; Okamoto Y ; Kominami E ; von Figura K ; Peters C ; Yamamoto K ; Saftig, Paul ; Uchiyama Y:
Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice .
In: J Neurosci (2001), Nr. 21, S. 7526-7533

Suter A ; Everts V ; Boyde A ; Jones SJ ; Lüllmann-Rauch R ; Hartmann D ; Hayman AR ; Cox TM ; Evans MJ ; Meister T ; von Figura K ; Saftig, Paul:
Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice .
In: Development (2001), Nr. 128, S. 4899-4910

Cupers P ; Bentahir M ; Craessaerts K ; Orlans I ; Vanderstichele H ; Saftig, Paul ; De Strooper B ; Annaert W:
The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein .
In: J Cell Biol (2001), Nr. 154, S. 731-740

Vincent B ; Paitel E ; Saftig, Paul ; Frobert Y ; Hartmann D ; De Strooper B ; Grassi J ; Lopez-Perez E ; Checler F:
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein .
In: J Biol Chem (2001), Nr. 276, S. 37743-37746

Tanaka Y ; Guhde G ; Suter A ; Eskelinen EL ; Hartmann D ; Lüllmann-Rauch R ; Janssen PM ; Blanz J ; von Figura K ; Saftig, Paul:
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice .
In: Nature (2000), Nr. 406, S. 902-906

Koike M ; Nakanishi H ; Saftig, Paul ; Ezaki J ; Isahara K ; Ohsawa Y ; Schulz-Schaeffer W ; Watanabe T ; Waguri S ; Kametaka S ; Shibata M ; Yamamoto K ; Kominami E ; Peters C ; von Figura K ; Uchiyama Y:
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons .
In: J Neurosci (2000), Nr. 20, S. 6898-6906

Roth W ; Deussing J ; Botchkarev VA ; Pauly-Evers M ; Saftig, Paul ; Hafner A ; Schmidt P ; Schmahl W ; Scherer J ; Anton-Lamprecht I ; Von Figura K ; Paus R ; Peters C:
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling .
In: FASEB J (2000), Nr. 14, S. 2075-2086

Heinrich M ; Wickel M ; Winoto-Morbach S ; Schneider-Brachert W ; Weber T ; Brunner J ; Saftig, Paul ; Peters C ; Krönke M ; Schütze S:
Ceramide as an activator lipid of cathepsin D .
In: Adv Exp Med Biol (2000), Nr. 477, S. 305-315

Saftig, Paul ; Hunziker E ; Everts V ; Jones S ; Boyde A ; Wehmeyer O ; Suter A ; von Figura K:
Functions of cathepsin K in bone resorption. Lessons from cathepsin K deficient mice .
In: Adv Exp Med Biol (2000), Nr. 477, S. 294-303

Meyer C ; Zizioli D ; Lausmann S ; Eskelinen EL ; Hamann J ; Saftig, Paul ; von Figura K ; Schu P:
mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors .
In: EMBO J (2000), Nr. 19, S. 2193-2203

Annaert W ; Cupers P ; Saftig, Paul ; De Strooper B:
Presenilin function in APP processing .
In: Ann N Y Acad Sci (2000), Nr. 920, S. 158-164

Rabini S ; Franke K ; Saftig, Paul ; Bode C ; Doenecke D ; Drabent B:
Spermatogenesis in mice is not affected by histone H1.1 deficiency .
In: Exp Cell Res (2000), Nr. 255, S. 114-124

Drabent B ; Saftig, Paul ; Bode C ; Doenecke D:
Spermatogenesis proceeds normally in mice without linker histone H1t .
In: Histochem Cell Biol (2000), Nr. 113, S. 433-442

De Strooper B ; Annaert W ; Cupers P ; Saftig, Paul ; Craessaerts K ; Mumm JS ; Schroeter EH ; Schrijvers V ; Wolfe MS ; Ray WJ ; Goate A ; Kopan R:
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain .
In: Nature (1999), Nr. 398, S. 518-522

Heinrich M ; Wickel M ; Schneider-Brachert W ; Sandberg C ; Gahr J ; Schwandner R ; Weber T ; Saftig, Paul ; Peters C ; Brunner J ; Krönke M ; Schütze S:
Cathepsin D targeted by acid sphingomyelinase-derived ceramide .
In: EMBO J (1999), Nr. 18, S. 5252-5263

Ray WJ ; Yao M ; Mumm J ; Schroeter EH ; Saftig, Paul ; Wolfe M ; Selkoe DJ ; Kopan R ; Goate AM:
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch .
In: J Biol Chem (1999), Nr. 274, S. 36801-36807

Zizioli D ; Meyer C ; Guhde G ; Saftig, Paul ; von Figura K ; Schu P:
Early embryonic death of mice deficient in gamma-adaptin .
In: J Biol Chem (1999), Nr. 274, S. 5385-5390

Andrejewski N ; Punnonen EL ; Guhde G ; Tanaka Y ; Lüllmann-Rauch R ; Hartmann D ; von Figura K ; Saftig, Paul:
Normal lysosomal morphology and function in LAMP-1-deficient mice .
In: J Biol Chem (1999), Nr. 274, S. 12692-12701

Herreman A ; Hartmann D ; Annaert W ; Saftig, Paul ; Craessaerts K ; Serneels L ; Umans L ; Schrijvers V ; Checler F ; Vanderstichele H ; Baekelandt V ; Dressel R ; Cupers P ; Huylebroeck D ; Zwijsen A ; Van Leuven F ; De Strooper B:
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency .
In: Proc Natl Acad Sci U S A (1999), Nr. 96, S. 11872-11877

Hartmann D ; De Strooper B ; Saftig, Paul:
Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly .
In: Curr Biol (1999), Nr. 9, S. 719-727

Villadangos JA ; Bryant RA ; Deussing J ; Driessen C ; Lennon-Duménil AM ; Riese RJ ; Roth W ; Saftig, Paul ; Shi GP ; Chapman HA ; Peters C ; Ploegh HL:
Proteases involved in MHC class II antigen presentation .
In: Immunol Rev (1999), Nr. 172, S. 109-120

Stinchi S ; Lüllmann-Rauch R ; Hartmann D ; Coenen R ; Beccari T ; Orlacchio A ; von Figura K ; Saftig, Paul:
Targeted disruption of the lysosomal alpha-mannosidase gene results in mice resembling a mild form of human alpha-mannosidosis .
In: Hum Mol Genet (1999), Nr. 8, S. 1365-1372

Saftig, Paul ; Hartmann D ; De Strooper B:
The function of presenilin-1 in amyloid beta-peptide generation and brain development .
In: Eur Arch Psychiatry Clin Neurosci (1999), Nr. 249, S. 271-279

Deussing J ; Roth W ; Saftig, Paul ; Peters C ; Ploegh HL ; Villadangos JA:
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation .
In: Proc Natl Acad Sci U S A (1998), Nr. 95, S. 4516-4521

De Strooper B ; Saftig, Paul ; Craessaerts K ; Vanderstichele H ; Guhde G ; Annaert W ; Von Figura K ; Van Leuven F:
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein .
In: Nature (1998), Nr. 391, S. 387-390

Zhang Z ; Hartmann H ; Do VM ; Abramowski D ; Sturchler-Pierrat C ; Staufenbiel M ; Sommer B ; van de Wetering M ; Clevers H ; Saftig, Paul ; De Strooper B ; He X ; Yankner BA:
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis .
In: Nature (1998), Nr. 395, S. 698-702

Saftig, Paul ; de Strooper B:
Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes .
In: Mol Psychiatry (1998), Nr. 3, S. 287-289

Saftig, Paul ; Hunziker E ; Wehmeyer O ; Jones S ; Boyde A ; Rommerskirch W ; Moritz JD ; Schu P ; von Figura K:
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice .
In: Proc Natl Acad Sci U S A (1998), Nr. 95, S. 13453-13458

Wu GS ; Saftig, Paul ; Peters C ; El-Deiry WS:
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity .
In: Oncogene (1998), Nr. 16, S. 2177-2183

Saftig, Paul ; Hartmann D ; Lüllmann-Rauch R ; Wolff J ; Evers M ; Köster A ; Hetman M ; von Figura K ; Peters C:
Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system .
In: J Biol Chem (1997), Nr. 272, S. 18628-18635

Wolff JR ; Liu WL ; Böttcher H ; Krizbai I ; Jóo F ; Saftig, Paul ; Parducz A:
Non-conventional role of lysosomal acid phosphatase in olfactory receptor axons: co-localization with growth-associated phosphoprotein-43 .
In: Neuroscience (1997), Nr. 79, S. 887-891

Saftig, Paul ; Peters C ; von Figura K ; Craessaerts K ; Van Leuven F ; De Strooper B:
Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D .
In: J Biol Chem (1996), Nr. 271, S. 27241-27244

Hess B ; Saftig, Paul ; Hartmann D ; Coenen R ; Lüllmann-Rauch R ; Goebel HH ; Evers M ; von Figura K ; D'Hooge R ; Nagels G ; De Deyn P ; Peters C ; Gieselmann V:
Phenotype of arylsulfatase A-deficient mice: relationship to human metachromatic leukodystrophy .
In: Proc Natl Acad Sci U S A (1996), Nr. 93, S. 14821-14826

Evers M ; Saftig, Paul ; Schmidt P ; Hafner A ; McLoghlin DB ; Schmahl W ; Hess B ; von Figura K ; Peters C:
Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VI .
In: Proc Natl Acad Sci U S A (1996), Nr. 93, S. 8214-8219

Saftig, Paul ; Hetman M ; Schmahl W ; Weber K ; Heine L ; Mossmann H ; Köster A ; Hess B ; Evers M ; von Figura K ; et al:
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells .
In: EMBO J (1995), Nr. 14, S. 3599-3608

Braulke T ; Claussen M ; Saftig, Paul ; Wendland M ; Neifer K ; Schmidt B ; Zapf J ; von Figura K ; Peters C:
Proteolysis of IGFBPs by cathepsin D in vitro and in cathepsin D-deficient mice .
In: Prog Growth Factor Res (1995), Nr. 6, S. 265-271

Hetman M ; Perschl A ; Saftig, Paul ; Von Figura K ; Peters C:
Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization .
In: DNA Cell Biol (1994), Nr. 13, S. 419-427

Köster A ; Saftig, Paul ; Matzner U ; von Figura K ; Peters C ; Pohlmann R:
Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins .
In: EMBO J (1993), Nr. 12, S. 5219-5223