Krossa, Sebastian ; Faust, Annette ; Ober, Dietrich ; Scheidig, Axel:
Comprehensive Structural Characterization of the Bacterial Homospermidine Synthase-an Essential Enzyme of the Polyamine Metabolism .
In: Sci Rep. (2016), S. 50

Weiße, RH ; Faust, A ; Schmidt, Marcel ; Schönheit, Peter ; Scheidig, Axel:
Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangement for phosphoryl transfer .
In: Proc Natl Acad Sci U S A (2016), S. 50-51

Zhang, R. ; Eckert, T. ; Lutteke, T ; Hanstein, S. ; Scheidig, Axel ; Bonvin, A. ; Nifantiev, N. ; Kozar, T. ; Schauer, Roland ; Enani, M. ; Professoren und Dozenten des Studiengangs Biochemie (B.Sc.):
Structure-Function Relationships of Antimicrobial Peptides and Proteins with Respect to Contact Molecules on Pathogen Surfaces .
In: Curr Top Med Chem (2016), Nr. 1, S. 89-98

Altmeyer, M. ; Amtmann, E. ; Heyl, C. ; Marschner, A. ; Scheidig, Axel ; Klein, C. D.:
Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases .
In: Bioorg. Med. Chem. Lett. (2015), Nr. 24, S. 5310-5314

Krossa, Sebastian ; Schmitt, A. D. ; Hatterman, K. ; Fritsch, J. ; Scheidig, Axel ; Mehdorn, H. M. ; Held-Feindt, Janka:
Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more effenciently than Twist-1 .
In: Oncotarget (2015), Nr. 11,

Knerlich-Lukoschus, Friederike ; Krossa, Sebastian ; Scheidig, Axel ; Mehdorn, H. Maximilian ; Scheidig, Axel ; Heldt-Feindt, J.:
Impact of chemokines on the properties of spinal cord-derived neural progenitor cells in a rat spinal cord lesion model .
In: J. Neurosci (2015), Nr. 93, S. 562-571

Frerichmann, S. L. ; Kirchhoff, M. ; Müller, A. E. ; Scheidig, Axel ; Jung, C. ; Kopisch-Obuch, F. J.:
EcoTILLING in Beta vulgaris reveals polymorphisms in the FLC-like gene BvFL1 that are associated with annuality and winter hardiness .
In: BMC Plant Biol (2013), Nr. 13, S. 52

Bräutigam, J. ; Scheidig, Axel ; Egge-Jacobsen, W.:
Mass spectrometric analysis of hepatitis C viral envelope protein E2 reveals extended microheterogeneity of mucin-type O-linked glycosylation .
In: Glycobiology (2013), Nr. 23, S. 453-474

Schuh, M. ; Scheidig, Axel ; Stosik, B. ; Kohring, G.-W. ; Giffhorn, F. ; Faust, Annette:
The structure of substrate-free 1,5-anhydro-D-fructose reductase from Sinorhizobium meliloti 1021 reveals an open enzyme conformation .
In: Acta Crystallogr (2013), Nr. F69, S. 844-849

Zander, U. ; Faust, A. ; Klink, B. U. ; de Sanctis, D. ; Panjikar, S. ; Quentmeier, A. ; Bardischewski, F. ; Friedrich, C. G. ; Scheidig, Axel:
Structural Basis for the Oxidation of Protein-bound Sulfur by the Sulfur Cycle Molybdohemo-Enzyme Sulfane Dehydrogenase SoxCD .
In: Journal of Biological Chemistry (2011), Nr. 286, S. 8349-8360

Klink, B.U. ; Scheidig, Axel:
New insight into the dynamic properties and the active site architecture of H-Ras p21 revealed by X-ray crystallography at very high resolution. .
In: BMC Structural Biology 10 (2010), S. 38

Petrareanu, G. ; Balasu, M.C. ; Zander, Uli ; Scheidig, Axel ; Szedlacsek, S.E.:
Preliminary X-ray crystallographic analysis of the D-xylulose 5-phosphate phosphoketolase from Lactococcus lactis. .
In: Acta Cryst. F 66 (2010), S. 805-807

Carius, Y. ; Christian, H. ; Scheidig, Axel ; Zander, Uli ; Klink, B.U. ; Kornberger, P. ; Kohring, G.W. ; Giffhorn, F. ; Faust, Annette:
Structural insight into substrate differentiation of the sugar-metabolizing enzyme galactitol dehydrogenase from Rhodobacter sphaeroides D. .
In: J. Biol. Chem. 285 (2010), S. 20006-20014

Carius, Yvonne ; Rother, D. ; Friedrich, C.G. ; Scheidig, Axel:
Crystal structure of the periplasmic thiol-disulfide oxidoreductase SoxS from Paracoccus pantotrophus indicates a triple Trx/Grx/DsbC functionality in chemotrophic sulfur oxidation. .
In: Acta Crystallogr. D 65 (2009), S. 229-240

Balasu, M.C. ; Spiridon, L.N. ; Miron, S. ; Craescu, C.T. ; Scheidig, Axel ; et al.:
Interface Analysis of the Complex between ERK2 and PTP-SL. .
In: PLoS ONE 4 (2009), Nr. 5,
[doi>10.1371/journal.pone.0005432]

Steinbach, A. ; Scheidig, Axel ; Klein, C.D.:
The unusual binding mode of cnicin tot he antibacterial target enzyme MurA revealed by X-ray crystallography. .
In: J. Med. Chemistry 51 (2008), S. 5143-5147

Lenz, T. ; Bonnist, E. ; Pljevaljcic, G. ; Neely, R.K. ; Dryden, D.T.F. ; Jones, A.C. ; Scheidig, Axel ; Weinhold, E.:
2-Aminopurine Flipped into the Active Site of the Adenine-Specific DNA Methyltransferase M.TaqI: Crystal Structures and Time-Resolved Fluorescence. .
In: J. Am. Chem. Soc. 129 (2007), S. 6240-6248

Pljevaljcic, G. ; Schmidt, F. ; Scheidig, Axel ; Lurz, R. ; Weinhold, E. :
Quantitative Labeling of Long Plasmid DNA with Nanometer Precision. .
In: ChemBioChem. 8 (2007), S. 1516-1519

Welsch, C. ; Albrecht, M. ; Maydt, J. ; Herrmann, E. ; Welker, M.W. ; Sarrazin, C. ; Scheidig, Axel ; Lengauer, T. ; Zeuzem, S. :
Structural and functional comparison of the non-structural protein 4B in flaviviridae. .
In: J. Mol. Graph. Model. 26 (2007), S. 546-557

Lübben, M. ; Güldenhaupt, J. ; Zoltner, M. ; Deigweiher, K. ; Haebel, P. ; Urbanke, C. ; Scheidig, Axel:
Sulfate acts as phosphate analog on the monomeric catalytic fragment of the CPx-ATPase CopB from Sulfolobus solfataricus. .
In: J. Mol. Biol. 369 (2007), S. 368-385

Klink, B.U. ; Goody, R.S. ; Scheidig, Axel:
A newly designed microspectro-fluorometer for kinetic studies on protein crystals in combination with x-ray diffraction. .
In: Biophysical J 91 (2006), S. 981-992

Dambe, T. ; Kühn, A. ; Brossette, T. ; Giffhorn, F. ; Scheidig, Axel:
Crystal structure of NADP(H) dependent 1,5-anhydro-D-fructose reductase from Sinorhizobium morelense at 2.2 Å resolution: Construction of a NADH-accepting mutant and its application in rare sugar synthesis. .
In: Biochemistry 45 (2006), S. 10030-10042

Huber, S. ; Scheidig, Axel:
High resolution crystal structures of human Rab4a in its active and inactive conformations. .
In: FEBS Lett 579 (2005), S. 2821-2829

Dambe, T. ; Quentmeier, A. ; Rother, D. ; Friedrich, C. ; Scheidig, Axel:
Structure of the cytochrome complex SoxXA of Paracoccus pantotrophus, a heme enzyme initiating chemotrophic sulfur oxidation. .
In: J.Struct. Biol. 152 (2005), S. 229-234

Harjes, S. ; Bayer, P. ; Scheidig, Axel:
The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate binding. .
In: J.Mol.Biol. 347 (2005), S. 623-635

Deigweiher, K. ; Drell, Th. L. IV ; Prutsch, A. ; Scheidig, Axel ; Lübben, M.:
Expression, isolation, and crystallization of the catalytic domain of CopB, a putative copper transporting ATPase from the thermoacidophilic archaeon sulfolobus solfataricus. .
In: J. Bioenerg. Biomemb. 36 (2004), S. 151-159

Harjes, S. ; Scheidig, Axel ; Bayer, P.:
Expression, purification and crystallization of human 3’-phosphoadenosine-5’-phosphosulfate synthetase 1. .
In: Acta Cryst. D60 (2004), S. 350-352

Lubben, M. ; Deigweiher, K. ; Haebel, P. ; Scheidig, Axel ; Peter, M.:
Structural studies on prokaryotic CPX-ATPases .
In: Biochimica Et Biophysica Acta-Bioenergetics (2004), Nr. 1658, S. 160-160

Gordeliy, V. ; Labahn, J. ; Moukhametzianov, R. ; Efremov, R. ; Granzin, J. ; Schlesinger, R. ; Buldt, G. ; Savopol, T. ; Scheidig, Axel ; Klare, J. P. ; Engelhard, M. :
Crystal structure of the sensory rhodopsin II-transducer complex: A molecular basis for transmembrane signalling. .
In: Biophysical Journal (2003), Nr. 84, S. 323a-323a

Friedrich, C. G. ; Quentmeier, A. ; Bardischewsky, F. ; Rother, D. ; Hellwig, P. ; Lubitz, W. ; Dambe, T. ; Scheidig, Axel:
The sulfur-oxidizing enzyme system of Paracoccus pantotrophus: protein and reaction. .
In: J. Inorg. Biochem. 96 (2003), S. 66

Constantinescu, A.-T. ; Rak, A. ; Alexandrov, K. ; Esters, H. ; Goody, R.S. ; Scheidig, Axel:
Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases. .
In: Structure 10 (2002), S. 569-579

Gordeliy, V. I. ; Labahn, J. ; Moukhametzianov, R. ; Efremov, R. ; Granzin, J. ; Schlesinger, R. ; Büldt, G. ; Savopol, T. ; Scheidig, Axel ; Klare, J.P. ; Engelhard, M.:
Structure of the sensory rhodopsin II/transducer complex: a molecular basis for transmembrane signalling. .
In: Nature 419 (2002), S. 484-487

Szedlacsek, S.E. ; Aricescu, A.R. ; Fulga, T.A. ; Renault, L. ; Scheidig, Axel:
Crystal structure of PTP-SL/PTPBR7 catalytic domain at 1.8 Å resolution: implications for MAP kinase regulation. .
In: J. Mol. Biol. 311 (2001), S. 557-568

Rak, A., ; Fedorov, R., ; Scheidig, Axel ; Goody, R. ; Alexandrov, K. :
Structural studies of vesicular transport components. .
In: Molecular Biology of the Cell (2001), Nr. 12, S. 216a-216a

Goedecke, K. ; Pignot, M. ; Goody, R.S. ; Scheidig, Axel ; Weinhold, E. :
Structure of the N6-adenine DNA methyltransferase M.TaqI in complex with DNA and a cofactor analog. .
In: Nature Struc. Biol. 8 (2001), S. 121-125

Esters, H. ; Alexandrov, K. ; Iakovenko, A. ; Ivanova, T. ; Thomae, N.H. ; Zerial, M. ; Scheidig, Axel ; Goody, R.S.:
Vps9, Rabex-5 and DSS4: Proteins with weak but distinct nucleotide-exchange activities for Rab proteins. .
In: J. Mol. Biol. 310 (2001), S. 141-156

Alexandrov, K. ; Scheidig, Axel ; Goody, R.S.:
Fluorescence methods for monitoring interactions of Rab proteins with nucleotides, Rab escort protein, and geranylgeranyltransferase. .
In: Marriott, G. (Hrsg.) : Methods in Enzymology.
Bd. 329. New York : Academic Press, 2000, S. 14-31.

Ester, H. ; Alexandrov, K. ; Constantinescu, A.-T. ; Goody, R. S. ; Scheidig, Axel:
High-resolution crystal structure of S. cerevisiae Ypt51(Δ C15)—GppNHp, a small GTP-binding protein involved in regulation of endocytosis. .
In: J. Mol. Biol. 298 (2000), S. 111-121

Thoma, N.H. ; Iakovenko, A. ; Owen, D. ; Scheidig, Axel ; Waldmann, H. ; Goody, R.S. ; Alexandrov, K. :
Phosphoisoprenoid Binding Specificity of Geranylgeranyltransferase Type II. .
In: Biochemistry 39 (2000), S. 12043-12052

Rak, A. ; Fedorov, R. ; Alexandrov, K. ; Albert, S. ; Goody, R.S. ; Gallwitz, D. ; Scheidig, Axel:
The crystal structure of the GAP domain of Gyp1p: first insights into the interaction and GTPase activation of Ypt/Rab proteins. .
In: EMBO J. 19 (2000), S. 5105-5113

Kuhl, H. ; Kruip, J. ; Seidler, A. ; Krieger-Liszkay, A. ; Bünker, M. ; Bald, D. ; Scheidig, Axel:
Toward structural determination of the water-splitting enzyme: Purification, crystallization and preliminary crystallographic studies of photosystem II from a thermophilic cyanobacterium. .
In: J. Biol. Chem. 275 (2000), S. 20652-20659

Gruen, M. ; Becker, Ch. ; Beste, A. ; Reinstein, J. ; Scheidig, Axel ; Goody, R.S.:
2’Halo-ATP and –GTP analogues: Rational phasing tools for protein crystallography. .
In: Protein Science 8 (1999), S. 2524-2528

Prinz, H. ; Lavie, A. ; Scheidig, Axel ; Spangenberg, O. ; Konrad, M.:
Binding of nucleotides to guanylate kinase, ras p21 and nucleoside diphosphate kinase studied by nano-electrospray mass spectrometry. .
In: J. Biol. Chem. 274 (1999), S. 35337-35342

Alexandrov, K. ; Simon, I. ; Yurchenko, Y. ; Iakovenko, A. ; Scheidig, Axel ; Goody, R.S.:
Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase. .
In: Eur. J. Biochem. 265 (1999), S. 160-170

Owen, D. ; Alexandrov, K. ; Rostkova, E. ; Scheidig, Axel ; Goody, R.S. ; Waldmann, H.:
Chemo-enzymatic synthesis of fluorescent Rab 7 proteins: Tools to study vesicular trafficking in cells. .
In: Angew. Chem. Int. Ed. 38 (1999), S. 509-512

Owen, D. ; Alexandrov, K. ; Rostkova, E. ; Scheidig, Axel ; Goody, R.S. ; Waldmann, H.:
Chemoenzymatische Synthese fluoreszierender Rab-7-Proteine: Werkzeuge zum Studium des vesikulären Transports in Zellen. .
In: Angew. Chem. 111 (1999), S. 570-573

Goody, R.S. ; Reinstein, J. ; Scheidig, Axel ; Schlichting, I.:
Die vierte Dimension in der makromolekularen Strukturforschung. .
In: Dortmunder UNI Report – Sonderheft 5 (1999), S. 40-45

Grün, M. ; Becker, C. ; Beste, A. ; Siethoff, C. ; Scheidig, Axel ; Goody, R.S.:
Synthesis of 2’-iodo and 2’-bromo ATP and GTP analogues as universal phasing tools for X-ray crystallography of ATP- and GTP-binding proteins. .
In: Nucleosides Nucleodides 18 (1999), S. 137-151

Scheidig, Axel ; Burmester, Ch. ; Goody, R.S.:
The pre-hydrolysis state of p21ras in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins. .
In: Structure 7 (1999), S. 1311-1324

Jones, A.T. ; Mills, I.G. ; Scheidig, Axel ; Alexandrov,K. ; Clague, M. J.:
Inhibition of endosome fusion by wortmannin persists in the presence of activated rab5. .
In: Mol. Biol. Cell. 9 (1998), S. 323-332

Alexandrov, K. ; Simon, I. ; Iakaovenko, A. ; Holz, B. ; Goody, R.S. ; Scheidig, Axel:
Moderate discrimination of Rep-1 between Rab7.GDP and Rab7.GTP arises from a difference of an order of magnitude in dissociation rates. .
In: FEBS Letters 425 (1998), S. 460-464

Cepus, V. ; Scheidig, Axel ; Goody, R.S. ; Gerwert, K.:
Time-resolved FTIR studies of the GTPase reaction of H-ras p21 reveal a key role for the beta-phosphate. .
In: Biochemistry 37 (1998), S. 10263-10271

Scheidig, Axel ; Burmester, C. ; Goody, R.S.:
Use of caged nucleotides to characterize unstable intermediates by X-ray crystallography. .
In: Marriott, G. (Hrsg.) : Methods in Enzymology.
Bd. 291. New York : Academic Press, 1998, S. 251-264.

Scheidig, Axel ; Hynes, T.R. ; Pelletier, L.A. ; Wells, J.A. ; Kossiakoff, A.A.:
Crystal structures of bovine chymotrypsin and trypsin complexes to the inhibitor domain of Alzheimer's amyloid ß-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): examples of binding modes of non-optimum P1 residues. .
In: Protein Science 6 (1997), S. 1806-1824

Wöhrl, B.M. ; Krebs, R. ; Thrall, S.H. ; Le Grice, S.F. ; Scheidig, Axel ; Goody, R.S.:
Kinetic analysis of four HIV-1 reverse transcriptase enzymes mutated in the primer grip region of p66. Implications for DNA synthesis and dimerization. .
In: J. Biol. Chem. 272 (1997), S. 17581-17587

Scheidig, Axel:
Time-resolved crystallography on p21H-ras. .
In: Rentzepis, Peter M. (Hrsg.) : Time-Resolved Electron and X-Ray Diffraction.
(Time-Resolved Electron and X-Ray Diffraction., San Diego, USA, 13.07.-14.07.1995). Bd. 2521.
1995, S. 278-289.

Scheidig, Axel ; Franken, S.M. ; Corrie, J.E.T. ; Reid, G.P. ; Wittinghofer, A. ; Pai, E.F. ; Goody, R.S.:
X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp. .
In: J. Mol. Biol. 253 (1995), S. 132-150

Scheidig, Axel ; Sanchez-Llorente, A. ; Lautwein, A. ; Pai, E.F. ; Corrie, J.E.T. ; Reid, G.P. ; Wittinghofer, A. ; Goody, R.S.:
Crystallographic studies on p21H-ras using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points. .
In: Acta Crystallogr., Ser. D 50 (1994), S. 512-520

Gerwert, K. ; Cepus, V. ; Scheidig, Axel ; Goody, R. S.:
Time-resolved FTIR studies of H-ras p21 GTPase activity. .
In: Proceedings of the Time-resolved Vibrational Spectroscopy Congress.
Berlin Heidelberg : Springer Verlag, 1994, S. 185-187.

Wittinghofer, A. ; Franken, S.M. ; Scheidig, Axel ; Rensland, H. ; Lautwein, A. ; Pai, E.F. ; Goody, R.S.:
Three-dimensional structure and properties of wild-type and mutant H-ras-encoded p21. .
In: Ciba Foundation Symposium 176 (1993), S. 6-27

Wittinghofer, A. ; Franken, S.M. ; Scheidig, Axel ; Rensland, H. ; Lautwein, A. ; Pai, E.F. ; Goody, R.S.:
Three-dimensional structure and properties of wild-type and mutant H-ras-encoded p21. .
In: Marsh, J.M. ; Goode, J. ; Wiley, John and Sons (Hrsg.) : The GTPase superfamily.
Chichester : Wiley Verlag, 1993, S. 6-27. - ISBN 0471939145

Franken, S.M. ; Scheidig, Axel ; Krengel, U. ; Rensland, H. ; Lautwein, A. ; Scheffzek, K. ; Geyer, M. ; Goody, R.S. ; Kalbitzer, H.-R. ; Pai, E.F. ; Wittinghofer, A.:
Three-dimensional structures and properties of a transforming and a nontransforming Glycine-12 mutant of p21H-ras. .
In: Biochemistry 32 (1993), S. 8411-8420

Goody, R.S. ; Pai, E.F. ; Schlichting, I. ; Rensland, H. ; Scheidig, Axel ; Franken, S. ; Wittinghofer, A.:
Studies on the structure and mechanism of H-ras p21. .
In: Phil. Trans. R. Soc. Lond. B 336 (1992), S. 3-11

Scheidig, Axel ; Pai, E.F. ; Schlichting, I. ; Corrie, J.E.T. ; Reid, G.P. ; Wittinghofer, A. ; Goody, R.S.:
Time resolved crystallography on H-ras p21. .
In: Phil. Trans. R. Soc. Lond., Ser. A 340 (1992), S. 263-272

Krengel, U. ; Schlichting, I. ; Scheidig, Axel ; Frech, M. ; John, J. ; Lautwein, A. ; Wittinghofer, A. ; Kabsch, W. ; Pai, E.F.:
The three-dimensioanl structure of p21 in the catalytically active conformation and analysis of oncogenic mutants. .
In: NATO ASI Ser., Ser. A (Superfamily ras-Relat. Genes) (1991), S. 183-193