Khundadze M ; Ribaudo F ; Hussain A ; Rosentreter J ; Nietzsche S ; Thelen M ; Winter D ; Hoffmann B ; Afzal MA ; Hermann T ; de Heus C ; Piskor EM ; Kosan C ; Franzka P ; von Kleist L ; Stauber T ; Klumperman J ; Damme, Markus ; Proikas-Cezanne T ; Hübner CA:
A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five .
In: Neurobiol Dis (2019), Nr. 127, S. 419-431

Moreau D ; Vacca F ; Vossio S ; Scott C ; Colaco A ; Paz Montoya J ; Ferguson C ; Damme, Markus ; Moniatte M ; Parton RG ; Platt FM ; Gruenberg J:
Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice .
In: EMBO Rep (2019), Nr. 20, S. e47055

Massa López D ; Thelen M ; Stahl F ; Thiel C ; Linhorst A ; Sylvester M ; Hermanns-Borgmeyer I ; Lüllmann-Rauch R ; Eskild W ; Saftig, Paul ; Damme, Markus:
The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP .
In: Elife (2019), Nr. 8, S. pii: e50025. doi: 10.7554/eLife.50025

Reinicke AT ; Laban K ; Sachs M ; Kraus V ; Walden M ; Damme, Markus ; Sachs W ; Reichelt J ; Schweizer M ; Janiesch PC ; Duncan KE ; Saftig, Paul ; Rinschen MM ; Morellini F ; Meyer-Schwesinger C:
Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks .
In: Proc Natl Acad Sci U S A (2019), Nr. 116, S. 7963-7972

Khateb S ; Kowalewski B ; Bedoni N ; Damme, Markus ; Pollack N ; Saada A ; Obolensky A ; Ben-Yosef T ; Gross M ; Dierks T ; Banin E ; Rivolta C ; Sharon D:
A homozygous founder missense variant in arylsulfatase G abolishes its enzymatic activity causing atypical Usher syndrome in humans .
In: Genet Med (2018), Nr. 20, S. 1004-1012

De Pace R ; Skirzewski M ; Damme, Markus ; Mattera R ; Mercurio J ; Foster AM ; Cuitino L ; Jarnik M ; Hoffmann V ; Morris HD ; Han TU ; Mancini GMS ; Buonanno A ; Bonifacino JS:
Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome .
In: PLoS Genet (2018), Nr. 14, S. e1007363

Gavin AL ; Huang D ; Huber C ; Mårtensson A ; Tardif V ; Skog PD ; Blane TR ; Thinnes TC ; Osborn K ; Chong HS ; Kargaran F ; Kimm P ; Zeitjian A ; Sielski RL ; Briggs M ; Schulz SR ; Zarpellon A ; Cravatt B ; Pang ES ; Teijaro J ; de la Torre JC ; O'Keeffe M ; Hochrein H ; Damme, Markus ; Teyton L ; Lawson BR ; Nemazee D:
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing .
In: Nat Immunol (2018), Nr. 19, S. 942-953

Gonzalez AC ; Stroobants S ; Reisdorf P ; Gavin AL ; Nemazee D ; Schwudke D ; D'Hooge R ; Saftig, Paul ; Damme, Markus:
PLD3 and spinocerebellar ataxia .
In: Brain (2018), Nr. 141, S. e78

Bartsch K ; Damme, Markus ; Regen T ; Becker L ; Garrett L ; Hölter SM ; Knittler K ; Borowski C ; Waisman A ; Glatzel M ; Fuchs H ; Gailus-Durner V ; Hrabe de Angelis M ; Rabe B:
RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation .
In: Front Immunol (2018), Nr. 9, S. 587

Gonzalez AC ; Schweizer M ; Jagdmann S ; Bernreuther C ; Reinheckel T ; Saftig, Paul ; Damme, Markus:
Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes .
In: Cell Rep (2018), Nr. 22, S. 1040-1053

Bartsch K ; Knittler K ; Borowski C ; Rudnik, Sönke ; Damme, Markus ; Aden, Konrad ; Spehlmann ME ; Frey, Norbert ; Saftig, Paul ; Chalaris A ; Rabe B:
Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy .
In: Hum Mol Genet (2017), Nr. 26, S. 3960-3972

Kissing S ; Rudnik S ; Damme, Markus ; Lüllmann-Rauch R ; Ichihara A ; Kornak U ; Eskelinen EL ; Jabs S ; Heeren J ; De Brabander JK ; Haas A ; Saftig, Paul:
Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes .
In: Autophagy (2017), Nr. 13, S. 670-685

Stroobants S ; Damme, Markus ; Van der Jeugd A ; Vermaercke B ; Andersson C ; Fogh J ; Saftig, Paul ; Blanz J ; D'Hooge R:
Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice .
In: Neurobiol Dis (2017), Nr. 106, S. 255-268

Lüningschrör P ; Binotti B ; Dombert B ; Heimann P ; Perez-Lara A ; Slotta C ; Thau-Habermann N ; R von Collenberg C ; Karl F ; Damme, Markus ; Horowitz A ; Maystadt I ; Füchtbauer A ; Füchtbauer EM ; Jablonka S ; Blum R ; Üçeyler N ; Petri S ; Kaltschmidt B ; Jahn R ; Kaltschmidt C ; Sendtner M:
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease .
In: Nat Commun (2017), Nr. 8, S. 678

Beel S ; Moisse MP ; Damme, Markus ; De Muynck L ; Robberecht W ; Van Den Bosch L ; Saftig, Paul ; Van Damme P:
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo .
In: Hum Mol Genet (2017), Nr. 26, S. 2850-2863

Markmann S ; Krambeck S ; Hughes CJ ; Mirzaian M ; Aerts JM ; Saftig, Paul ; Schweizer M ; Vissers JP ; Braulke T ; Damme, Markus:
Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II. .
In: Mol Cell Proteomics (2017), Nr. 16, S. 438-450

Seipold L ; Damme, Markus ; Prox J ; Rabe B ; Kasparek P ; Sedlacek R ; Altmeppen H ; Willem M ; Boland B ; Glatzel M ; Saftig, Paul:
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein .
In: Biochim Biophys Acta Mol Cell Res (2017), Nr. 1864, S. 217-230

Wolf H ; Damme, Markus ; Stroobants S ; D'Hooge R ; Beck HC ; Hermans-Borgmeyer I ; Lüllmann-Rauch R ; Dierks T ; Lübke T:
A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease .
In: Dis Model Mech (2016), Nr. 9, S. 1015-1028

Nesset CK ; Kong XY ; Damme, Markus ; Schjalm C ; Roos N ; Løberg EM ; Eskild W:
Age-dependent development of liver fibrosis in Glmp (gt/gt) mice .
In: Fibrogenesis Tissue Repair (2016), Nr. 9, S. 5

Kruszewski K ; Lüllmann-Rauch R ; Dierks T ; Bartsch U ; Damme, Markus:
Degeneration of Photoreceptor Cells in Arylsulfatase G-Deficient Mice .
In: Invest Ophthalmol Vis Sci (2016), Nr. 57, S. 1120-1131

Klionsky DJ ; große Vielzahl von Autoren ; Saftig, Paul ; Damme, Markus ; große Vielzahl von Autoren ; Zughaier SM:
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) .
In: Autophagy (2016), Nr. 12, S. 1-222

Kowalewski B ; Heimann P ; Ortkras T ; Lüllmann-Rauch R ; Sawada T ; Walkley SU ; Dierks T ; Damme, Markus:
Ataxia is the major neuropathological finding in arylsulfatase G-deficient mice: similarities and dissimilarities to Sanfilippo disease (mucopolysaccharidosis type III) .
In: Hum Mol Genet (2015), Nr. 24, S. 1856-1868

Damme, Markus ; Suntio T ; Saftig, Paul ; Eskelinen EL:
Autophagy in neuronal cells: general principles and physiological and pathological functions .
In: Acta Neuropathol (2015), Nr. 129, S. 337-362

Damme, Markus ; Stroobants S ; Lüdemann M ; Rothaug M ; Lüllmann-Rauch R ; Beck HC ; Ericsson A ; Andersson C ; Fogh J ; D'Hooge R ; Saftig, Paul ; Blanz J:
Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice .
In: Ann Clin Transl Neurol (2015), Nr. 2, S. 987-1001

Varga RE ; Khundadze M ; Damme, Markus ; Nietzsche S ; Hoffmann B ; Stauber T ; Koch N ; Hennings JC ; Franzka P ; Huebner AK ; Kessels MM ; Biskup C ; Jentsch TJ ; Qualmann B ; Braulke T ; Kurth I ; Beetz C ; Hübner CA:
In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11 .
In: PLoS Genet (2015), Nr. 11, S. e1005454

Kong XY ; Kase ET ; Herskedal A ; Schjalm C ; Damme, Markus ; Nesset CK ; Thoresen GH ; Rustan AC ; Eskild W:
Lack of the Lysosomal Membrane Protein, GLMP, in Mice Results in Metabolic Dysregulation in Liver .
In: PLoS One (2015), Nr. 10, S. e0129402

Peters J ; Rittger A ; Weisner R ; Knabbe J ; Zunke F ; Rothaug M ; Damme, Markus ; Berkovic SF ; Blanz J ; Saftig, Paul ; Schwake M:
Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease .
In: Biochem Biophys Res Commun (2015), Nr. 457, S. 334-340

Blanz J ; Zunke F ; Markmann S ; Damme, Markus ; Braulke T ; Saftig, Paul ; Schwake M:
Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2 .
In: Traffic (2015), Nr. 16, S. 1127-1136

Götzl JK ; Mori K ; Damme, Markus ; Fellerer K ; Tahirovic S ; Kleinberger G ; Janssens J ; van der Zee J ; Lang CM ; Kremmer E ; Martin JJ ; Engelborghs S ; Kretzschmar HA ; Arzberger T ; Van Broeckhoven C ; Haass C ; Capell A:
Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis .
In: Acta Neuropathol (2014), Nr. 127, S. 845-860

Damme, Markus ; Brandenstein L ; Fehr S ; Jankowiak W ; Bartsch U ; Schweizer M ; Hermans-Borgmeyer I ; Storch S:
Gene disruption of Mfsd8 in mice provides the first animal model for CLN7 disease .
In: Neurobiol Dis (2014), Nr. 65, S. 12-24

Kong XY ; Nesset CK ; Damme, Markus ; Løberg EM ; Lübke T ; Mæhlen J ; Andersson KB ; Lorenzo PI ; Roos N ; Thoresen GH ; Rustan AC ; Kase ET ; Eskild W:
Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells .
In: Dis Model Mech (2014), Nr. 7, S. 351-362

Kowalewski B ; Lübke T ; Kollmann K ; Braulke T ; Reinheckel T ; Dierks T ; Damme, Markus:
Molecular characterization of arylsulfatase G: expression, processing, glycosylation, transport, and activity .
In: J Biol Chem (2014), Nr. 289, S. 27992-28005

Jae LT ; Raaben M ; Herbert AS ; Kuehne AI ; Wirchnianski AS ; Soh TK ; Stubbs SH ; Janssen H ; Damme, Markus ; Saftig, Paul ; Whelan SP ; Dye JM ; Brummelkamp TR:
Virus entry. Lassa virus entry requires a trigger-induced receptor switch .
In: Science (2014), Nr. 344, S. 1506-1510

Kowalewski B ; Lamanna WC ; Lawrence R ; Damme, Markus ; Stroobants S ; Padva M ; Kalus I ; Frese MA ; Lübke T ; Lüllmann-Rauch R ; D'Hooge R ; Esko JD ; Dierks T:
Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice .
In: Proc Natl Acad Sci U S A (2012), Nr. 109, S. 10310-10315

Thelen M ; Damme, Markus ; Schweizer M ; Hagel C ; Wong AM ; Cooper JD ; Braulke T ; Galliciotti G:
Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis .
In: PLoS One (2012), Nr. 7, S. e35493

Kollmann K ; Damme, Markus ; Markmann S ; Morelle W ; Schweizer M ; Hermans-Borgmeyer I ; Röchert AK ; Pohl S ; Lübke T ; Michalski JC ; Käkelä R ; Walkley SU ; Braulke T:
Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice .
In: Brain (2012), Nr. 135, S. 2661-2675

Makrypidi G ; Damme, Markus ; Müller-Loennies S ; Trusch M ; Schmidt B ; Schlüter H ; Heeren J ; Lübke T ; Saftig, Paul ; Braulke T:
Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5 .
In: Mol Cell Biol (2012), Nr. 32, S. 774-782

Damme, Markus ; Stroobants S ; Walkley SU ; Lüllmann-Rauch R ; D'Hooge R ; Fogh J ; Saftig, Paul ; Lübke T, Blanz J ; Blanz J:
Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in a-mannosidosis .
In: J Neuropathol Exp Neurol (2011), Nr. 70, S. 83-94

Savalas LR ; Gasnier B ; Damme, Markus ; Lübke T ; Wrocklage C ; Debacker C ; Jézégou A ; Reinheckel T ; Hasilik A ; Saftig, Paul ; Schröder B:
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L .
In: Biochem J (2011), Nr. 439, S. 113-128

Damme, Markus ; Morelle W ; Schmidt B ; Andersson C ; Fogh J ; Michalski JC ; Lübke T:
Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis .
In: Mol Cell Biol (2010), Nr. 30, S. 273-283

Kollmann K ; Damme, Markus ; Deuschl F ; Kahle J ; D'Hooge R ; Lüllmann-Rauch R ; Lübke T:
Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1 .
In: FEBS J (2009), Nr. 276, S. 1356-1369

Schieweck O ; Damme, Markus ; Schröder B ; Hasilik A ; Schmidt B ; Lübke T:
NCU-G1 is a highly glycosylated integral membrane protein of the lysosome .
In: Biochem J (2009), Nr. 422, S. 83-90